Table 2 Biological functions responding to RA treatment and RXRα knockout in wild type mice
Gene number (with RXRα bindings) | ||||||||
|---|---|---|---|---|---|---|---|---|
Biological functions | RA induced & RXRα KO repressed | RA repressed & RXRα KO induced | ||||||
Lipid droplet growth | 1 | (0) | 2 | (2) | ||||
Transportation of bile aicds for bile excretion | 1 | (0) | 0 | |||||
Dehydrogenation of saturated fatty acids to unsaturated fatty acids | 3 | (2) | 0 | |||||
Biosynthesis of glycerol phosphalipids | 4 | (3) | 1 | (1) | ||||
Tryglyceride degration | 4 | (3) | 0 | |||||
Biosynthesis of unsaturated fatty acids responsible for aniti-inflammation | 9 | (7) | 0 | |||||
Elimination of retinoic acids | 13 | (11) | 0 | |||||
Biosynthesis of bile acids | 4 | (4) | 4 | (4) | ||||
Biosynthesis of retinoic acids | 1 | (1) | 2 | (2) | ||||
Biosynthesis of saturated fatty acids | 5 | (5) | 10 | (10) | ||||
Degradation of glycerol phosphalipids | 1 | (1) | 4 | (4) | ||||
Degradation of saturated fatty acids | 10 | (10) | 5 | (5) | ||||
Elimination of steroid hormones | 3 | (3) | 5 | (5) | ||||
Fat digestion and absorption | 3 | (3) | 7 | (7) | ||||
Lipid droplet breakdown (fat mobilization) | 1 | (1) | 1 | (1) | ||||
Recycle of bile acids via hepatic-intestine | 1 | (1) | 3 | (3) | ||||
S1P degradation | 1 | (1) | 1 | (1) | ||||
Transportation of bile aicds for kidney excretion | 2 | (2) | 3 | (3) | ||||
DHS1P degradation | 1 | (1) | 0 | |||||
Elimination of unsaturated fatty acids (PGE2) responsible for lipolysis inhibition | 1 | (1) | 0 | |||||
phosphatidylcholine to phosphatidylethanolamine | 1 | (1) | 0 | |||||
Sphingolipid biosynthesis | 1 | (1) | 0 | |||||
SPH (SM) degradation | 0 | 1 | (0) | |||||
Biosynthesis of cholesterol | 0 | 10 | (10) | |||||
Biosynthesis of steroid hormone | 0 | 1 | (1) | |||||
Biosynthesis of tryglycerides | 0 | 1 | (1) | |||||
Biosynthesis of unsaturated fatty acids responsible for pro-inflammation | 0 | 1 | (1) | |||||
Breakdown of phosphalipid to form unsaturated fatty acids | 0 | 1 | (1) | |||||
Elimination of cholesterol (from cyculation back to liver for catabolism) | 0 | 1 | (1) | |||||
Elimination of cholesterol via steoid hormone pathway | 0 | 1 | (1) | |||||
Phosphatidylethanolamine to phosphatidylcholine | 0 | 1 | (1) | |||||