From: Genome-wide modeling of complex phenotypes in Caenorhabditis elegans and Drosophila melanogaster
C. elegans | ||
---|---|---|
Large gene sets | Number | Genes |
embryonic lethal | 3301 | AC7.1(tag-49), AC7.10, AC7.13, AC7.19, AC7.68, AC8.6, AH6.5, B0001.2, B0025.2 9(csn.2), B0025.5, etc… |
larval arrest | 1688 | AC8.6, B0025.1(vps-34), B0035.10(his-45), B0035.11, B0035.12, B0035.7(his-47), B0035.8(his-48), B0205.6, B0238.11, B0250.1, etc… |
slow growth | 1664 | AC3.7, AC8.6, B0024.4, B0025.1(vps-34), B0025.2, B0025.5, B0025.6, B0035.10(his-45), B0035.11, B0035.12, etc… |
locomotion variant | 1414 | AH6.5 (mex-6), B0025.1(vps-34), B0035.11, B0035.12, B0035.14(dn-j1), B0035.15, B0035.7(his-47), B0035.8(his-48), B0035.9(his-46), B0207.4(air-2), etc… |
maternal sterile | 1107 | AC7.1(tag-49), AC7.10, AC7.13, AC7.19, AC7.68, AC8.6, B0024.14, B0025.2, B0025.5, B0035.10(his-45), etc… |
reduced brood size | 975 | AC8.1, AC8.2, B0035.10(his-45), B0035.11, B0041.4(rpl-4), B0205.6, B0207.4(air-2), B0252.9, B0261.2(let-363), B0261.4, etc… |
sterile | 889 | B0035.11, B0035.8(HIS-48), B0041.4(RPL-4), B0205.6, B0212.4, B0284.1, B0284.6, B0285.1, B0286.4(NTL-2), B0304.1(HLH-1), etc… |
larval lethal | 834 | AC7.11, AC7.15, AC7.18, AC7.2(soc-2), AC7.22, AC7.29, AC7.33, AC7.4, AC7.6, AC7.65, etc… |
Intermediate gene sets | ||
cytokinesis fails early emb | 57 | B0207.4(air-2), B0273.2(puf-7), C01F6.3, C03C10.3(rnr-2), C07H6.5(cgh-1), C08B11.1(zyzg-11), C09G4.3(cks-1), C17G10.4(CDC-14), C25A1.9(rsa-1), C32E8.8(ptr-2), etc… |
cell cycle slow early emb | 56 | C03C10.3(rnr-2), C08B11.1(zyzg-11), C14B9.4(plk-1), C26D10.2(hel-1), C27A2.3(ify-1), C30C11.2(rpn-3), C33H5.15(sgo-1), C40H5.6, C40H5.8, C47E12.5(uba-1), etc… |
pharyngeal pumping reduced | 49 | B0348.4(egl-8), B0365.3(eat-6), B0412.2(daf-7), B0495.4(nhx-2), C02C6.1(dyn-1), C05D2.1(daf-4), C09B7.1(ser-7), C09B7.10, C09B7.12, C09B7.9, etc… |
pronuclear size defective early emb | 43 | B0035.12, C08B11.1(zyzg-11), C08B6.9, C26D10.1(ran-3), C27A2.3(ify-1), C28C12.2, C37A2.4(cye-1), C38D4.3(mel-28), C40H5.6, C40H5.8, etc… |
bag of worms | 38 | B0348.4(egl-8), B0412.2(daf-7), C04A2.3(egl-27), C04G2.7(egl-38), C05D9.5(ife-4), C08C3.1(egl-5), C26E6.8(ula-1), C30A5.7(uno-86), C44B12.2(ost-1), C46F4.1, etc… |
exaggerated asynchrony early emb | 36 | C03C10.3(rnr-2), C25D7.6(mcm-3), C26D10.1(ran-3), C28C12.2, C29A12.3(lig-1), C38D4.3(mel-28), C39E9.13(rfc-3), C40H5.6, C40H5.8, C54G10.2(rfc-1), etc… |
organism osmotic stress response var. | 34 | B0218.3(pmk-1), C12C8.1(hsp-70), C32E12.3(osr-1), C53B4.12, C53D6.18, F07C6.7, F10D2.9(fat-7), F11C7.5(osm-11), F19H8.1(tps-2), F38E11.1(hsp-12.3), etc… |
dead eggs laid | 27 | C09D4.5(rpl-19), C27A2.2(rpl-22), C36E8.5(tbb-2), C47B2.3(tba-2), C53A5.1(ril-1), C54C6.2(ben-1), F25B5.4(ubq-1), F26D10.3(hsp-1), F26E4.8(tba-1), F44F4.11(tba-4), etc… |
Small gene sets | ||
neuron function reduced | 8 | F36F2.5(tax-2), F55A8.2(egl-4), K03A11.3(ceh-28), K03A11.8, ZC416.8(unc-17), ZC84.2(tax-4), ZK1290.18, ZK1290.2(tph-1) |
neuron morphology variant | 8 | C10A4.8(mnm-2), C35C5.4(mig-2), C44B11.3(mec-12), F28D1.10(gex-3), K10G9.3(pad-2), T01E8.4, Y51H4A.3, ZK154.3(mec-7) |
pheromone induced dauer form. enhan | 7 | C38C3.5(unc-60), F02E8.6(ncr-1), F02E8.9, F55A8.2(egl-4), T20B5.3(oga-1), Y44A6D.4(sdf-9), Y6B3B.11(hsd-1) |
programmed cell death variant | 7 | C07H6.7(lin-39), C09G4.1(hyl-1), F31E3.1(ceh-20), T07C4.8(ced-9), T12F5.4(lin-59), T28F12.2(unc-62), Y6B3B.10(lag-1) |
cell division slow | 6 | C26D10.1(ran-3), C29E4.3(ran-2), F26B1.3(ima-2), F28B3.8(imb-1), K01G5.4(ran-1), ZK328.5(npp-10) |
ectopic neurite outgrowth | 6 | B0285.5(hse-5), C35C5.4(mig-2), C39F7.2, F41C6.1(unc-6), T19B4.7(unc-40), T24B8.6(hlh-3) |
dauer cuticle variant | 5 | C47G2.1(cut-1), C47G2.15, F22B5.3(cut-3), M142.2(cut-6), ZC328.1 |
endosome biogenesis variant | 5 | F49E7.1(rme-6), F58G6.1(amph-1), W06B4.3(vps-18), Y39A1A.5(rabx-5), Y49E10.11(tat-1) |
D. melanogaster | ||
Large gene sets | Number | Genes |
macrochaeta | 927 | arc, abb, abr, ac, Act5C, ade2, ade3, amb, aop, Appl, etc… |
male sterile | 854 | abd-A, Abd-B, abt, ac, ade2, amb, ano, aop, ap, ar, etc… |
wing vein | 768 | abd-A, Abd-B, abt, abw, ac, ade2, ade3, al, aop, ap, etc… |
pigment cell | 708 | ade2, ade3, amb, aop, arm, bi, bo, bos, br, brb, etc… |
ommatidium | 704 | a, Abd-B, Abl, abr, abt, ald, amx, aop, apx, arm, etc… |
neurophysiology defective | 404 | Abl, Ace, acj6, Appl, Arr2, bas, baz, bi, bsk, bss, etc… |
short lived | 235 | ap, cad, car, Cat, cm, comt, dnc, dor, ecd, EcR, etc… |
body color defective | 229 | Abd-B, abt, amb, asx, b, bi, Bkd, br, cal, crm, etc… |
Intermediate gene sets | ||
hyperplasia | 67 | arm, bam, cg, cos, Dl, ds, eyg, gd, ft, ImpL2, etc… |
size defective | 67 | aop, arm, bi, dpp, ds, ena, ft, gt, Hsc70-4, L, etc… |
learning defective | 62 | agn, cab, cbd, ccb, ccd, Ddc, dnc, eag, Fas2, G-salpha60A, etc… |
increased cell size | 55 | brm, fkh, Hsc70-4, swm, mod, phl, Ras85D, shi, stg, Egfr, etc… |
wing sensillum | 54 | arm, arr, ase, bi, brm, clm, Dr, dsh, eg, fu, etc… |
scutum | 53 | abd-A, Abd-B, ac, ap, Bx, Pka-C1, Dl, dpp, Dr, ds, etc… |
cell death defective | 51 | DNaseII, dor, dsh, EcR, dco, numb, Ras85D, rst, W, Top1, etc… |
large body | 44 | ImpL2, l(2)gl, phl, Ras85D, rl, tkd, tor, tsh, gig, CycD, etc… |
Small gene sets | Â | Â |
optic chiasm | 8 | bi, rst, so, sim, ato, tutl, Scer\GAL4, elav |
CNS glial cell | 7 | E(z), sws, gcm, Scer\GAL4, spdo, hkb, vnd |
adult myoblast | 7 | slou, N, Rac1, insc, Scer\GAL4, Hsap\CDKN1A, tw |
sex comb tooth | 7 | Pc, Scr, ph-p, Scer\GAL4, KG01932, 5-SZ-3716, Zzzz\Aobl-tra |
abdominal 3 seg. border muscle | 6 | if, numb, mys, insc, Tig, Scer\GAL4 |
epidermal cell | 6 | ed, pim, tkv, ct, Scer\GAL4, exo84 |
glomerulus | 6 | dnc, Wnt5, Cdc42, Scer\GAL4, drl, Drl-2 |
mesothoracic cleft | 6 | bsk, kay, pnr, Scer\GAL4, park, puc |