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Table 1 Selected Phenotype gene sets

From: Genome-wide modeling of complex phenotypes in Caenorhabditis elegans and Drosophila melanogaster

C. elegans

Large gene sets

Number

Genes

embryonic lethal

3301

AC7.1(tag-49), AC7.10, AC7.13, AC7.19, AC7.68, AC8.6, AH6.5, B0001.2, B0025.2 9(csn.2), B0025.5, etc…

larval arrest

1688

AC8.6, B0025.1(vps-34), B0035.10(his-45), B0035.11, B0035.12, B0035.7(his-47), B0035.8(his-48), B0205.6, B0238.11, B0250.1, etc…

slow growth

1664

AC3.7, AC8.6, B0024.4, B0025.1(vps-34), B0025.2, B0025.5, B0025.6, B0035.10(his-45), B0035.11, B0035.12, etc…

locomotion variant

1414

AH6.5 (mex-6), B0025.1(vps-34), B0035.11, B0035.12, B0035.14(dn-j1), B0035.15, B0035.7(his-47), B0035.8(his-48), B0035.9(his-46), B0207.4(air-2), etc…

maternal sterile

1107

AC7.1(tag-49), AC7.10, AC7.13, AC7.19, AC7.68, AC8.6, B0024.14, B0025.2, B0025.5, B0035.10(his-45), etc…

reduced brood size

975

AC8.1, AC8.2, B0035.10(his-45), B0035.11, B0041.4(rpl-4), B0205.6, B0207.4(air-2), B0252.9, B0261.2(let-363), B0261.4, etc…

sterile

889

B0035.11, B0035.8(HIS-48), B0041.4(RPL-4), B0205.6, B0212.4, B0284.1, B0284.6, B0285.1, B0286.4(NTL-2), B0304.1(HLH-1), etc…

larval lethal

834

AC7.11, AC7.15, AC7.18, AC7.2(soc-2), AC7.22, AC7.29, AC7.33, AC7.4, AC7.6, AC7.65, etc…

Intermediate gene sets

cytokinesis fails early emb

57

B0207.4(air-2), B0273.2(puf-7), C01F6.3, C03C10.3(rnr-2), C07H6.5(cgh-1), C08B11.1(zyzg-11), C09G4.3(cks-1), C17G10.4(CDC-14), C25A1.9(rsa-1), C32E8.8(ptr-2), etc…

cell cycle slow early emb

56

C03C10.3(rnr-2), C08B11.1(zyzg-11), C14B9.4(plk-1), C26D10.2(hel-1), C27A2.3(ify-1), C30C11.2(rpn-3), C33H5.15(sgo-1), C40H5.6, C40H5.8, C47E12.5(uba-1), etc…

pharyngeal pumping reduced

49

B0348.4(egl-8), B0365.3(eat-6), B0412.2(daf-7), B0495.4(nhx-2), C02C6.1(dyn-1), C05D2.1(daf-4), C09B7.1(ser-7), C09B7.10, C09B7.12, C09B7.9, etc…

pronuclear size defective early emb

43

B0035.12, C08B11.1(zyzg-11), C08B6.9, C26D10.1(ran-3), C27A2.3(ify-1), C28C12.2, C37A2.4(cye-1), C38D4.3(mel-28), C40H5.6, C40H5.8, etc…

bag of worms

38

B0348.4(egl-8), B0412.2(daf-7), C04A2.3(egl-27), C04G2.7(egl-38), C05D9.5(ife-4), C08C3.1(egl-5), C26E6.8(ula-1), C30A5.7(uno-86), C44B12.2(ost-1), C46F4.1, etc…

exaggerated asynchrony early emb

36

C03C10.3(rnr-2), C25D7.6(mcm-3), C26D10.1(ran-3), C28C12.2, C29A12.3(lig-1), C38D4.3(mel-28), C39E9.13(rfc-3), C40H5.6, C40H5.8, C54G10.2(rfc-1), etc…

organism osmotic stress response var.

34

B0218.3(pmk-1), C12C8.1(hsp-70), C32E12.3(osr-1), C53B4.12, C53D6.18, F07C6.7, F10D2.9(fat-7), F11C7.5(osm-11), F19H8.1(tps-2), F38E11.1(hsp-12.3), etc…

dead eggs laid

27

C09D4.5(rpl-19), C27A2.2(rpl-22), C36E8.5(tbb-2), C47B2.3(tba-2), C53A5.1(ril-1), C54C6.2(ben-1), F25B5.4(ubq-1), F26D10.3(hsp-1), F26E4.8(tba-1), F44F4.11(tba-4), etc…

Small gene sets

neuron function reduced

8

F36F2.5(tax-2), F55A8.2(egl-4), K03A11.3(ceh-28), K03A11.8, ZC416.8(unc-17), ZC84.2(tax-4), ZK1290.18, ZK1290.2(tph-1)

neuron morphology variant

8

C10A4.8(mnm-2), C35C5.4(mig-2), C44B11.3(mec-12), F28D1.10(gex-3), K10G9.3(pad-2), T01E8.4, Y51H4A.3, ZK154.3(mec-7)

pheromone induced dauer form. enhan

7

C38C3.5(unc-60), F02E8.6(ncr-1), F02E8.9, F55A8.2(egl-4), T20B5.3(oga-1), Y44A6D.4(sdf-9), Y6B3B.11(hsd-1)

programmed cell death variant

7

C07H6.7(lin-39), C09G4.1(hyl-1), F31E3.1(ceh-20), T07C4.8(ced-9), T12F5.4(lin-59), T28F12.2(unc-62), Y6B3B.10(lag-1)

cell division slow

6

C26D10.1(ran-3), C29E4.3(ran-2), F26B1.3(ima-2), F28B3.8(imb-1), K01G5.4(ran-1), ZK328.5(npp-10)

ectopic neurite outgrowth

6

B0285.5(hse-5), C35C5.4(mig-2), C39F7.2, F41C6.1(unc-6), T19B4.7(unc-40), T24B8.6(hlh-3)

dauer cuticle variant

5

C47G2.1(cut-1), C47G2.15, F22B5.3(cut-3), M142.2(cut-6), ZC328.1

endosome biogenesis variant

5

F49E7.1(rme-6), F58G6.1(amph-1), W06B4.3(vps-18), Y39A1A.5(rabx-5), Y49E10.11(tat-1)

D. melanogaster

Large gene sets

Number

Genes

macrochaeta

927

arc, abb, abr, ac, Act5C, ade2, ade3, amb, aop, Appl, etc…

male sterile

854

abd-A, Abd-B, abt, ac, ade2, amb, ano, aop, ap, ar, etc…

wing vein

768

abd-A, Abd-B, abt, abw, ac, ade2, ade3, al, aop, ap, etc…

pigment cell

708

ade2, ade3, amb, aop, arm, bi, bo, bos, br, brb, etc…

ommatidium

704

a, Abd-B, Abl, abr, abt, ald, amx, aop, apx, arm, etc…

neurophysiology defective

404

Abl, Ace, acj6, Appl, Arr2, bas, baz, bi, bsk, bss, etc…

short lived

235

ap, cad, car, Cat, cm, comt, dnc, dor, ecd, EcR, etc…

body color defective

229

Abd-B, abt, amb, asx, b, bi, Bkd, br, cal, crm, etc…

Intermediate gene sets

hyperplasia

67

arm, bam, cg, cos, Dl, ds, eyg, gd, ft, ImpL2, etc…

size defective

67

aop, arm, bi, dpp, ds, ena, ft, gt, Hsc70-4, L, etc…

learning defective

62

agn, cab, cbd, ccb, ccd, Ddc, dnc, eag, Fas2, G-salpha60A, etc…

increased cell size

55

brm, fkh, Hsc70-4, swm, mod, phl, Ras85D, shi, stg, Egfr, etc…

wing sensillum

54

arm, arr, ase, bi, brm, clm, Dr, dsh, eg, fu, etc…

scutum

53

abd-A, Abd-B, ac, ap, Bx, Pka-C1, Dl, dpp, Dr, ds, etc…

cell death defective

51

DNaseII, dor, dsh, EcR, dco, numb, Ras85D, rst, W, Top1, etc…

large body

44

ImpL2, l(2)gl, phl, Ras85D, rl, tkd, tor, tsh, gig, CycD, etc…

Small gene sets

  

optic chiasm

8

bi, rst, so, sim, ato, tutl, Scer\GAL4, elav

CNS glial cell

7

E(z), sws, gcm, Scer\GAL4, spdo, hkb, vnd

adult myoblast

7

slou, N, Rac1, insc, Scer\GAL4, Hsap\CDKN1A, tw

sex comb tooth

7

Pc, Scr, ph-p, Scer\GAL4, KG01932, 5-SZ-3716, Zzzz\Aobl-tra

abdominal 3 seg. border muscle

6

if, numb, mys, insc, Tig, Scer\GAL4

epidermal cell

6

ed, pim, tkv, ct, Scer\GAL4, exo84

glomerulus

6

dnc, Wnt5, Cdc42, Scer\GAL4, drl, Drl-2

mesothoracic cleft

6

bsk, kay, pnr, Scer\GAL4, park, puc