miRNAs and gene expression in normal colon mucosa, primary tumor and liver metastases. (A) Sample classification based on 309 miRNAs and 15,761 gene expression profiles. Color-coding of samples reported in different lines refers to tissue type (Normal colon mucosa, N; primary colorectal cancer, T and liver metastasis, M) and per-patient matching of samples. (B) miRNA and gene expression variability in two main tumor progression transitions. (C) Venn diagram of intersections among DEMs identified by unpaired test applied to different comparisons.