Post-transcriptional regulatory network of miRNAs down-modulated in T vs N contrast. (A) The bipartite network represents DEMs down-modulated (FC > 3) in T vs N comparison (green triangles), supported target genes (circles) and their relations (gray dotted lines). Target DEGs in T vs N contrast are shown in orange, other genes in grey. The pink solid line outlines an experimentally validated relation. (B) Inverse correlation between c-Myc and miR-145 expression according to quantitative qRT-PCR in 78 samples of N, T and M samples used for gene profiling. Quantification normalized to expression of DACT1 and miR-200c, respectively. Data shown as means ± standard deviation (SD) of mean of three experiments performed in triplicate. **P < 0.01 vs N. nRQ: normalized Relative Quantity.