GRASP [Genomic Resource Access for Stoichioproteomics]: comparative explorations of the atomic content of 12 Drosophila proteomes

Table 2 Number of proteins (out of 4934) showing significant evolutionary relationships (using PGLM, threshold p = 0.01; see Methods for details) between principal component (PC) axes and ecological/genomic traits of interest (for hypotheses, see Table 1 ; for PC axis loadings, see Figure 1 )

Trait	Number of significant relationships
	PC1	PC2	PC3	PC4	PC5	PC6	PC7	PC8
Genome size	49	44	49	36	13	21	25	26
Intron percent	651	561	493	539 ⁺	349 ^-	313 ⁺	363	475
Dimorphism	73	58	47	82	22	27	34	53
Thorax width	128	104	49	99	33	35	50	86
Specific development time	393	309	272	267 ⁺	170	161	197	270
Development time	118	86	31	87	31	33	37	79
Diet breadth	302*	229*	200 ^-	229	119⁺	120	148^-	205 ⁺
Ovariole number	394	288	260	311	162	179	195	250

Values over 200, or 4 × the expected number of proteins, we deemed significant and are given in bold. +/− in superscript indicates that regression coefficients are biased towards positive or negative values (binomial sign tests). Asterisk indicates the sign of coefficients are unevenly distributed among protein functional categories (χ² tests).

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