Table 1 A list of psychotropic drugs selected for the comparison
| Â | Drug | Dose [mg/kg, i.p.] (control)1 | Pharmacological targets | Clinical group7 |
|---|---|---|---|---|
1 | Mianserin (MIA)3 | 20 (sal) | HRH1 / HTR2C, 2A, 3A / ADRA2C, 2A, 1A / NET / CHRM | Antidepressant (NaSSa) |
2 | Imipramine (IMI)3 | 10 (sal) | SERT / HRH1 / NET / ADRA1A / HTR2C / CHRM | Antidepressant (TCA) |
3 | Fluoxetine (FLU)3 | 20 (sal) | SERT / NET / HTR2C | Antidepressant (SSRI) |
4 | Bupropion (BUP)3 | 20 (sal) | DAT | Antidepressant (DRI) |
5 | Tianeptine (TIA)2 | 20 (sal) | Unknown targets | Antidepressant (SSRE) |
6 | Tranylcypromine (TRA)2 | 20 (sal) | MAO | Antidepressant (MAOI) |
7 | Methamphetamine (MET)2 | 2 (sal) | NET / DAT | Psychostimulant |
8 | Cocaine (COC)2 | 25 (sal) | DAT / NET / SERT | Psychostimulant |
9 | Nicotine (NIC)2 | 1 (sal) | n-AChR | Psychostimulant |
10 | Heroin (HER)6 | 10 (sal) | OPRM1, OPRK1, OPRD1 | Analgesic |
11 | Morphine (MOR)4 | 20 (sal) | OPRM1, OPRK1, OPRD1 | Analgesic |
12 | Ethanol (ETO)2 | 2000 (sal) | GABAA | Anxiolytic/Analgesic |
13 | Diazepam (DIA)2 | 5 (twe) | GABAA | Anxiolytic |
14 | Buspirone (BUS)3 | 10 (sal) | 5HT1A | Anxiolytic |
15 | Hydroxizine (HYD)2 | 10 (sal) | HRH1 | Anxiolytic |
16 | Clozapine (CLO)3 | 3 (twe) | DRD4, 2 / HRH1 / HTR2A, 2C / DRD1 / CHRM / ADRA1A | Antipsychotic |
17 | Risperidone (RIS)3 | 0.5 (twe) | HTR2A, 2C / DRD1 / DRD2, 3, 4 / ADRA1A, 2C / HRH1 | Antipsychotic |
18 | Haloperidol (HAL)3 | 1 (twe) | DRD2, 3, 4 / 5HT2 | Antipsychotic |
19 | Tween 802 | vol. 10 ml/kg (naïve) | No targets | Vehicle |
20 | Saline (SAL)5 | vol. 10 ml/kg (naïve) | No targets | Vehicle |