Distribution of abundant gene clusters in Mycobacterium. Six common secondary metabolite gene clusters with possibly informative phylogenetic distributions are shown from Mycobacterium. The tree is a subtree of that shown in Figure 1. Strains shown in blue contain the gene cluster indicated and strains shown in black do not. All strains above JDM601 are nonpathogenic or rarely opportunistic pathogens; branches leading to pathogenic strains are colored red. While none of these gene clusters have identical distribution patterns, the data suggest that some are important enough to be conserved for pathogenesis and others may be more useful in soil or aquatic habitats. Genome IDs used in this figure are: MAB, Mycobacterium abscessus ATCC 19977T; MSMEG, Mycobacterium smegmatis str. MC2 155; Mflv, Mycobacterium gilvum PYR-GCK; Mspyr1, Mycobacterium sp. Spyr1; Mjls, Mycobacterium sp. JLS; Mkms, Mycobacterium sp. KMS; Mmcs, Mycobacterium sp. MCS; JDM601, Mycobacterium sp. JDM601; MAP, Mycobacterium avium subsp. Paratuberculosis K-10; MAV, Mycobacterium avium 104; MUL, Mycobacterium ulcerans Agy99; MMAR, Mycobacterium marinum M; MLBr, Mycobacterium leprae Br4923; MCAN, Mycobacterium canettii CIPT 140010059; Rv, Mycobacterium tuberculosis H37RvT; Mb, Mycobacterium bovis AF2122/97; and MAF, Mycobacterium africanum GM041182.