Figure 1
From: “Non-canonical protein-DNA interactions identified by ChIP are not artifacts”: response
DNA binding to low and high probe-density microarrays. On low density microarrays, enriched DNA fragments bind to a single probe (A). This leads to a single strong signal. On high density microarrays the same DNA can bind to more than one specific probe (B). This decreases the signal intensity but increases the number of signals to be used for binding site detection. The dynamic range of raw data will thus be decreased compared to low density microarrays but not the data quality.