Figure 1

Genome comparison of three propionibacteria. A) All CDS of P. avidum 440677 (two red outer rings, representing CDS on plus and minus strand) were compared by bidirectional blast with all CDS of P. avidum ATCC25577 (orange) and P. avidum TM16 (yellow), P. acnes KPA (blue), P. acnes 266 (light blue), P. granulosum TM11 (green), and P. granulosum DSM20700 (marine). Gaps indicate the absence of CDS homologs of P. avidum 44067 in the respective genomes. The inner ring (in purple and olive) represents the G + C content distribution of the P. avidum 44067 genome (window size 10000 bp, step size 200 bp). The most inner circle depicts predicted islands (in red) possibly acquired by horizontal gene transfer (predictions from IslandViewer; results from two different algorithms are shown: orange, Sigi-HMM; blue, IslandPath-DIMOB). P. avidum harbors 7 genomic regions that are predicted to be horizontally acquired. Please see also Additional file 3 for the genome comparisons of P. granulosum TM11 and P. acnes KPA. B) A VENN diagram depicts the number of species-specific CDS and those shared by all three propionibacteria. The three-way comparison is based on bidirectional blast results (Additional file 2). 1380 CDS have homologs in all three propionibacteria (>25% amino acid identity), which represents 76%, 61% and 60% of all CDS in P. granulosum TM11, P. avidum 44067 and P. acnes KPA, respectively.