Fimbriae/Pili-encoding loci in the genome of P. granulosum . A and B) Two loci in the P. granulosum genome encode sortases (designated here SrtA-D). These genes are clustered with genes encoding proteins similar to fimbriae/pilin subunits of Corynebacterium sp. (designated here SpaB, SpaC, SpaD, SpaF and SpaI, based on their sequence similarity to pilin subunits of Corynebacterium diphtheriae). These proteins carry a C-terminal LPXTG motif (boxed genes). The two genetic loci are absent from the genomes of P. acnes KPA and 266 and P. avidum ATCC25577 and 44067. P. granulosum TM11 and P. acnes KPA were used for this illustration; the genomes of P. granulosum DSM20700 and P. acnes 266 are highly similar in the depicted genomic regions. Same colors and numbers depict homologies between CDS of different species.