Comparative genomics reveals that a fish pathogenic bacterium Edwardsiella tarda has acquired the locus of enterocyte effacement (LEE) through horizontal gene transfer

Nakamura, Yoji; Takano, Tomokazu; Yasuike, Motoshige; Sakai, Takamitsu; Matsuyama, Tomomasa; Sano, Motohiko

doi:10.1186/1471-2164-14-642

Table 5 Comparison of reported virulence genes among E. tarda strains

From: Comparative genomics reveals that a fish pathogenic bacterium Edwardsiella tarda has acquired the locus of enterocyte effacement (LEE) through horizontal gene transfer

Gene or gene cluster	Description	Accession No.	Reference	HT^†	EIB202	NUF806	FL6-60	E22	FPC503	93_146	ATCC23685	SU100	SU117	SU138	SU244
hhaEt	α-hemolysisn-modulator like protein	YP_003295064	[10]	X^§	+	+	+	+	+	+	+	+	+	+	+
papA	P pilus assembly protein, pilin FimA	YP_003296301	[10]	X	+	+	+	+	+	-	-	-	-	-	-
papC	P pilus assembly protein, porin PapC	YP_003296298	[10]	X	+	+	+	+	+	?	?	?	?	?	?
papD	chaperone protein PapD	YP_003296297	[10]	X	+	+	+	+	+	?	?	?	?	?	?
papH	minor pilin subunit PapH	YP_003296299	[10]	X	+	+	?	+	+	-	-	-	-	-	-
papK	hypothetical protein	YP_003296296	[10]	X	+	+	?	+	+	-	-	-	-	-	-
aidA	putative autotransporter protein	BAH03175	[15]		-	-	-	-	+	+	-	-	-	-	-
sodB	iron-containing superoxide disumutase	BAA84480	[31]		+	+	+	+	+	+	+	+	+	+	+
ethA	hemolysin	BAA21097	[32]		+	+	+	+	+	+	+	+	+	+	+
ethB	activation/secretion protein	BAA21096	[32]		+	+	+	+	+	+	+	+	+	+	+
qseB	DNA-binding transcriptional regulator	ADO13165	Direct submission		+	+	+	+	+	+	+	+	+	+	+
qseC	sensor protein	ADO24152	[33]		+	+	+	+	+	+	+	+	+	+	+
phoP	phoP	ADB28435	[34]		+	+	+	+	+	+	+	+	+	+	+
phoQ	phoQ	ADB28436	[34]		+	+	+	+	+	+	+	+	+	+	+
phoU	repressor protein	AAN05785	[35]		+	+	+	+	+	+	+	+	+	+	+
fimABCD	type 1 fimbrial protein	BAC55512-3, BAD00163-4	[35, 36]		+	+	+	+	+	+	+	+	+	+	+
ankB	ankyrin B	AAL82720	[35]	X	+	+	?	+	+	-	-	-	-	-	-
citC	citrate lyase ligase	AAO52821	[35]		+	+	+	+	+	+	+	+	+	+	+
gadB	glutamate decarboxylase	AAL82718	[35]		+	+	+	+	+	+	+	+	+	+	+
isoR	Fe-S oxidoreductase	AAL82723	[35]		+	+	+	+	+	+	+	+	+	+	+
katB	catalase precursor	AAL82719	[35]	X	+	+	+	+	+	-	-	-	-	-	-
mukF	putative killing factor	AAL82725	[35]		+	+	+	+	+	+	+	+	+	+	+
ompS2	outer membrane protein	AAL82724	[35]		+	+	+	+	+	+	+	+	+	+	+
orf20	hypothetical protein	AAL82721	[35]		-	-	-	-	-	-	-	-	-	-	-
orfA	unknown protein	AAL01251	[35]		+	+	+	+	+	+	-	-	-	-	-
pstA	transport membrane protein A	AAN05783	[35]		+	+	+	+	+	+	+	+	+	+	+
pstB	ATP binding protein	AAN05784	[35]		+	+	+	+	+	+	+	+	+	+	+
pstC	transport membrane protein C	AAN05782	[35]		+	+	+	+	+	+	+	+	+	+	+
pstS	phosphate binding protein	AAO52825	[35]		+	+	+	+	+	+	+	+	+	+	+
flagellin	flagellin	AAN52540	[37]		+	+	+	+	+	+	+	+	+	+	+
esa, esc, ese, esr	Type III secretion system loci	AAV69401- AAX76924^*	[37]		+	+	+	+	+	+	-	-	-	-	-
evp	Type VI secretion system locus	AAR83927 - ABW69087^*	[38]	evpP ^‡	+	+	+	+	+	+	-	-	-	-	-

Denotation: ‘+’, present (amino acid identity >= 60%); ‘-’, absent; ‘?’, weekly similar (amino acid identity < 60%).
*All accession numbers are shown in Additional file 7: Table S2.
^†Whether horizontally transferred or not was predicted.
^§HT was predicted in fish-pathogens.
^‡A gene evpP in this locus was predicted as horizontally transferred.

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ISSN: 1471-2164

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