Summary of the integrated genomic analysis of miR-17-92 and miR-106b-25 clusters. (a) DNA gains and losses respectively occurring in the miRNA clusters genomic locations. Frequencies of DNA gains (Y axis, green colour) and losses (Y axis, red colour) along the genome sequence (X axis) are represented. Data refer to the selected sub-cohort of basal-like tumours. (b) DNA gains in genomic regions 13q31.3 and 7q22.1 drive the up-regulation of the respective miRNA clusters in basal-like tumours. The two paired panels show miRNA cluster expression across tumours with DNA gains (orange), losses (white), no changes (yellow) of the respective loci (left) and different intrinsic subtypes (right) (c) down-stream effects observed to be driven, at the transcriptional level, by the up-regulation miR-17-92 and miR-106b-25 clusters in basal-like tumours.