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Figure 2 | BMC Genomics

Figure 2

From: Genome mining reveals the genus Xanthomonas to be a promising reservoir for new bioactive non-ribosomally synthesized peptides

Figure 2

Representation of the NRPS loci META-A, META-B and META-C of X. albilineans strain GPE PC73. Brown arrow: staM gene predicted to be required for β−hydroxylation of an unidentified amino acid. Purple arrow: daT gene predicted to be required for biosynthesis of Dab (2,4-diamino butyric acid). Orange arrows: genes predicted to be required for biosynthesis of Dpg (3,5-dihydroxyphenylglycine). Dark blue arrows: other genes conserved in all META-B loci (ABC transporter, MbtH-like protein and transcriptional regulator AraC). Black arrows: NRPS genes. Length of arrows is not proportional to the length of genes. NRPS modules are represented by circles. Large circles indicate complete NRPS modules (containing domains C, A and PCP). The amino acid predicted to be assembled by the corresponding module is indicated within each circle. ?X: unknown amino acid specific to the NRPS signature UnknownX (Additional file 1). Brown circles: NRPS modules predicted to be specific for tyrosine. Purple circles: NRPS modules predicted to be specific to Dab. Orange circles: NRPS modules predicted to be specific to Dpg. The sequential order of amino acid incorporation from the N- to the C-terminus is illustrated by the number above each circle. Small black circles represent TE domains. The starter module circled in red exhibits a C-domain belonging to the same phylogenetic clade as starter C-domains identified by Rausch et al. [6] (Additional file 2). Starter modules circled in green indicate a C-domain belonging to the distant phylogenetic clade containing starter C-domains of loci META-A and META-C (Additional file 2). Elongation modules circled in blue indicate a C-domain belonging to the same phylogenetic clade as dual C/E domains identified by Rausch et al. [6] (Additional file 2). Amino acids predicted to be epimerized by these domains are in blue. IS: insertion sequence. Dotted box: pseudogene.

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