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Table 2 Similarities between genes predicted to be required for biosynthesis of Dpg in strain GPE PC73 of Xanthomonas albilineans and genes previously characterized from strain DSM 5908 of Amycolatopsis balhimycina[42] and from strain NRRL15009 of Streptomyces toyocaensis[40]

From: Genome mining reveals the genus Xanthomonas to be a promising reservoir for new bioactive non-ribosomally synthesized peptides

Genes of strain GPE PC73 Genes of strain DSM 5908 of A. balhimycina Overall amino acid identities / similarities with genes of strain DSM 5908 Genes of strain NRRL15009 of S. toyocaensis Overall amino acid identities / similarities with genes of strain NRRL15009 Functions
XALc_1059 DpgA (CAC48378) 55% / 69% DpgA (AAM80548) 54% / 67% Type III chalcone synthase, generates 3,5-dihydroxyphenylacetyl-CoA from four malonyl-CoA
XALc_1060 DpgB (CAC48379) 31% / 46% DpgB (AAM80547) 29% / 45% Belongs to crotonase/Enoyl-CoA hydratase superfamily, enhances DpgA activity
XALc_1061 DpgC (CAC48380) 48% / 62% DpgC (AAM80546) 48% / 62% Metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase, converts 3,5-dihydroxyphenylacetyl-CoA into 3,5-dihydroxyphenylglyoxylate*
XALc_1062 HpgT (CAC48367) 43% / 58% HpgT (AAM80549) 42% / 58% Transaminase, generates 3,5-dihydroxyphenyl-glycine from 3,5-dihydroxyphenylglyoxylate
XALc_1063 DpgD (CAC48381) 62% / 74% DpgD (AAM80545) 61% / 74% Belongs to crotonase/Enoyl-CoA hydratase superfamily, enhances DpgA activity
  1. * This function was characterized for biosynthesis of vancomycin [43].