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Table 2 Similarities between genes predicted to be required for biosynthesis of Dpg in strain GPE PC73 of Xanthomonas albilineans and genes previously characterized from strain DSM 5908 of Amycolatopsis balhimycina[42] and from strain NRRL15009 of Streptomyces toyocaensis[40]

From: Genome mining reveals the genus Xanthomonas to be a promising reservoir for new bioactive non-ribosomally synthesized peptides

Genes of strain GPE PC73

Genes of strain DSM 5908 of A. balhimycina

Overall amino acid identities / similarities with genes of strain DSM 5908

Genes of strain NRRL15009 of S. toyocaensis

Overall amino acid identities / similarities with genes of strain NRRL15009

Functions

XALc_1059

DpgA (CAC48378)

55% / 69%

DpgA (AAM80548)

54% / 67%

Type III chalcone synthase, generates 3,5-dihydroxyphenylacetyl-CoA from four malonyl-CoA

XALc_1060

DpgB (CAC48379)

31% / 46%

DpgB (AAM80547)

29% / 45%

Belongs to crotonase/Enoyl-CoA hydratase superfamily, enhances DpgA activity

XALc_1061

DpgC (CAC48380)

48% / 62%

DpgC (AAM80546)

48% / 62%

Metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase, converts 3,5-dihydroxyphenylacetyl-CoA into 3,5-dihydroxyphenylglyoxylate*

XALc_1062

HpgT (CAC48367)

43% / 58%

HpgT (AAM80549)

42% / 58%

Transaminase, generates 3,5-dihydroxyphenyl-glycine from 3,5-dihydroxyphenylglyoxylate

XALc_1063

DpgD (CAC48381)

62% / 74%

DpgD (AAM80545)

61% / 74%

Belongs to crotonase/Enoyl-CoA hydratase superfamily, enhances DpgA activity

  1. * This function was characterized for biosynthesis of vancomycin [43].