Figure 1

Gene expression differences between the control and 17β-trenbolone (TB) exposed female G . holbrooki as determined by hierarchical cluster analysis. Genes with fold changes > 1.5 fold or < −1.5 fold over controls and with one-way ANOVA p-values < 0.05 were used for this analysis, and 279 genes were found to be down-regulated by TB exposure and 229 genes up-regulated by TB exposure. Data were median-centered by gene and clustered using centered correlation and complete linkage. Yellow genes are more highly expressed than the gene average and blue genes are expressed at a lower level than the gene average. The resulting gene expression map demonstrates the distinct hepatic expression profiles of the vehicle control-exposed and TB exposed groups.