Genome-wide analysis of human hotspot intersected genes highlights the roles of meiotic recombination in evolution and disease

Table 2 Summary of gene datasets

Dataset	Description	Updated	Genes	Reference
hg18rpa	Protein-coding genes on autosomal chromosomes (based on human genome hg18 and RefSeq genes)	2011	18,166	[35]
HI	Recombination hotspots intersected genes	2010	1,156	-
MI	Recombination middle spots intersected genes	2010	1,481	-
CI	Recombination cold spots intersected genes	2010	1,594	-
HK	Housekeeping genes	2011	1,974	[36]
SPD	Genes encoding secreted proteins	2010	1,667	[37]
TiGER	Tissue-specific genes	2008	4,710	[38]
DGD	Duplicated genes	2012	4,393	[16]
AGE	Genes classified by different evolutionary age	2011	16,418	[17]
OMIM	Mendelian disorder associated genes in human	2012	2,624	[39]
MD	Mendelian Disease Genes (at least one mutation in the particular gene is causative of the disease)	2011	1,629	[21]
CGC	Genes with mutations have been causally implicated in cancer	2011	424	[23]
TICdb	Reciprocal translocation associated genes in human tumours	2008	240	[40]
dbCRID	Chromosomal rearrangement associated genes in human diseases	2010	401	[22]
InteCR	Integrated chromosomal rearrangement associated genes in human diseases (Combined of dbCRID, TICdb and CGC genes)	2012	614	-

Summary of gene datasets used in this study. All datasets are mapped to hg18rpa. Gene numbers are counted according to non-redundant official gene symbols. Note that HI, MI and CI genes are defined in this study as mentioned above. Detailed gene lists are given in Additional file 3.

ISSN: 1471-2164