Figure 6
From: The shaping and functional consequences of the dosage effect landscape in multiple myeloma
The correlation between dosage sensitive genes and CNA frequency across chromosomes. (A) The proportion of genes in each chromosome that are dosage sensitive (DES > 0.4). X-axis: the IFM dataset, Y-axis: the Dickens dataset. (B) The proportion of genes in each chromosome that have medium dosage effect (0.2 < = DES < = 0.4). X-axis: the IFM dataset, Y-axis: the Dickens dataset. (C) Copy number alteration frequency in each chromosome compared between the two datasets. Each point represents the CNA (copy number <1.7 or > 2.3) frequency of a gene across samples, averaged over all the genes in a chromosome. (D, E) The proportion of dosage sensitive genes (Y-axis) is plotted against the average CNA frequency (X-axis) for different chromosomes, for the IFM data (D) and the Dickens data (E).