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Figure 2 | BMC Genomics

Figure 2

From: Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood–brain barrier disruption

Figure 2

QTL analysis of functional motor deficits, CNS vascular permeability, and astrocyte activation. Log-likelihood plots of (A) functional motor deficits as measured by rotarod performance, (B) CNS vascular permeability as measured by leakage of FITC-albumin into the CNS, and (C) astrocyte activation as measured by GFAP expression. The upper graph charts the data as a LOD score. The solid black line depicts the significance threshold. The lower graph depicts the estimated QTL effects. Significant LOD scores were obtained for (A) functional motor deficits, which is shown to map to chromosome 12 (LOD = 3.3), and (B) CNS vascular permeability, which is shown to map to chromosome 17 (LOD = 3.7).

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BMC Genomics

ISSN: 1471-2164

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