A. SNP | Low F2s (n=145) | High F2s (n=128) | Chi-square test | Chi-square p-value | LOD score |
---|
| BB | BS | SS | BB | BS | SS | | | |
---|
rs6292954 | 18 | 80 | 47 | 50 | 51 | 27 | 25.93 | 0.000002 | 3.65 |
rs13481303 | 17 | 83 | 45 | 46 | 56 | 26 | 22.71 | 0.000012 | 3.66 |
rs3655057 | 19 | 80 | 46 | 46 | 54 | 28 | 19.66 | 0.000054 | 3.30 |
rs13481324 | 21 | 79 | 45 | 49 | 52 | 27 | 20.28 | 0.000039 | 3.35 |
B. SNP
|
Low F2s (n=182)
|
High F2s (n=91)
|
Chi-square test
|
Chi-square p-value
|
LOD Score
|
|
BB
|
BS
|
SS
|
BB
|
BS
|
SS
| | | |
rs6196216 | 58 | 88 | 36 | 20 | 39 | 32 | 8.24 | 0.016245 | 3.73 |
rs3672065 | 60 | 85 | 37 | 19 | 39 | 33 | 9.27 | 0.009706 | 3.79 |
- 2 × 3 contingency tables comparing B6 homozygous (BB), heterozygous (BS), and 129S1 homozygous (SS) mice with regards to (A) functional motor deficits as measured by rotarod performance and (B) CNS vascular permeability as measured by leakage of FITC-albumin into the CNS. (A) Mice displaying <50% initial ability were placed in the low F2 group, while mice displaying >50% initial ability were placed in the high F2 group. 129S1 contributes to low rotarod performance on chromosome 12 markers rs6292954, rs13481303, rs3655057, and rs13481324, while B6 contributes to high rotarod performance on these markers. (B) The low F2 group consists of mice with FITC scores <500, while the high F2 group consists of mice with FITC scores >500. B6 contributes to less CNS vascular permeability on chromosome 17 markers rs6196216 and rs3672065, while 129S1 contributes to more CNS vascular permeability on these markers.