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Table 1 Chi-square analysis of functional deficit and CNS vascular permeability

From: Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood–brain barrier disruption

A. SNP

Low F2s (n=145)

High F2s (n=128)

Chi-square test

Chi-square p-value

LOD score

 

BB

BS

SS

BB

BS

SS

   

rs6292954

18

80

47

50

51

27

25.93

0.000002

3.65

rs13481303

17

83

45

46

56

26

22.71

0.000012

3.66

rs3655057

19

80

46

46

54

28

19.66

0.000054

3.30

rs13481324

21

79

45

49

52

27

20.28

0.000039

3.35

B. SNP

Low F2s (n=182)

High F2s (n=91)

Chi-square test

Chi-square p-value

LOD Score

 

BB

BS

SS

BB

BS

SS

   

rs6196216

58

88

36

20

39

32

8.24

0.016245

3.73

rs3672065

60

85

37

19

39

33

9.27

0.009706

3.79

  1. 2 × 3 contingency tables comparing B6 homozygous (BB), heterozygous (BS), and 129S1 homozygous (SS) mice with regards to (A) functional motor deficits as measured by rotarod performance and (B) CNS vascular permeability as measured by leakage of FITC-albumin into the CNS. (A) Mice displaying <50% initial ability were placed in the low F2 group, while mice displaying >50% initial ability were placed in the high F2 group. 129S1 contributes to low rotarod performance on chromosome 12 markers rs6292954, rs13481303, rs3655057, and rs13481324, while B6 contributes to high rotarod performance on these markers. (B) The low F2 group consists of mice with FITC scores <500, while the high F2 group consists of mice with FITC scores >500. B6 contributes to less CNS vascular permeability on chromosome 17 markers rs6196216 and rs3672065, while 129S1 contributes to more CNS vascular permeability on these markers.