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Table 3 Genes of interest potentially related to B6 and 129S1 phenotypic differences in CD8 T cell-initiated BBB disruption

From: Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood–brain barrier disruption

Chromosome 12 (Rotarod)

Proposed function

# SNPs different between strains

SNP locations

Vsnl1

Neuronal Ca2+ sensor proteins

24

All I

Ddx1

Viral responses

2

All I

Trib2

Induces apoptosis of cells in hematopoietic origin; CD8 T cells

40

1 Cs, 1 U5, 38 I

Lpin1

Demyelination; actin cytoskeleton reorganization

531

3 Cn, 8 Cs, 27 U3, 493 I

Kcnf1

Neurotransmitter release; neuronal excitability

35

4 Cs, 7 U5, 24 U3

Rock2

Actin cytoskeleton organization; regulation of angiogenesis

330

1 Cn, 3 Cs, 5 U3, 321 I

Chromosome 17 (CNS vascular permeability)

Proposed function

# SNPs different between strains

SNP locations

Pde10a

Signal transduction; neuronal cell bodies

1268

Unspecified

Qk

Myelinization; axon ensheathment; vasculogenesis

214

12 U3, 202 I

Pacrg

Myelinization

265

2 U5, 263 I

Park2

Neuron projection; neuron death

3198

2 Cs, 1 U3, 3195 I

Plg

Apoptotic processes; vessel development

38

1 Cn, 37 I

Igf2r

Edema

7

All I

Mas1

Inflammatory responses

2

All I

Mllt4

Adherens junctions; cell junctions

7

All I

  1. Shown are the genes of interest found on chromosome 12 and chromosome 17 along with their proposed functions. The Mouse Phenome Database (http://www.phenome.jax.org) was used to determine the number of SNPs that are different between the B6 and 129S1 mouse strains as well as their location.
  2. (Abbreviations: Cn nonsynonomous codon, Cs synonomous codon, U5 51 UTR variant, U3 31 UTR variant, I intron-variant).