Table 2 Hotspot description
Hotspot | Localizationa | Number of eQTLb | Functional enrichment | Phenotypic QTL | Knowon or candidate gene regulator | Functional validation | Comments |
|---|---|---|---|---|---|---|---|
1 | chr2:207 | 66 | No functional enrichment | Pyruvate | SCT1 | Not realized | Hidden by the disomy, Sct1p is involved in lipid desaturation and diverges in the two strains by the size of a glutamic acid repeated sequence |
2 | chr2:277 | 47 | No functional enrichment | - | Unknow | - | Hidden by the disomy |
3 | chr2:560 | 7 | Daughter cell separation | Clumpness, OD, cell pop. | AMN1 | Yvert et al. 2003 [34] | Impacting on cellular population estimation |
4 | chr3:198 | 20 | Mating, pheromone | - | MAT | Brem et al. 2005 [35] | Â |
5 | chr4:309 | 9 | Thiamine synthesis | - | THI3 | Not realized | THI3 bears two non-synonymous SNPs and a frame-shift in its coding sequence |
6 | chr8:20 | 27 | Helicase | - | - | - | Disomy consequence |
7 | chr10:590 | 18 | Mitochondrial protein | - | GRR1 | Not realized | GRR1 has a strong cis-eQTL (LOD = 13.4) and several alteration of its coding sequence |
8 | chr12:667 | 33 | Fatty acid metabolism, detoxification | - | HAP1/PDR8 | Yvert et al. 2003 [34] | Genes involved in the response to oxygen (nine targets of HAP1, Additional file 5) |
9 | chr14:456 | 101 | Mitochondrial protein | Succinate, Glycerol | MKT1 | Smith and Kruglyak 2008 [25] | Perturbation of the mitochondrial function affect the production of metabolites |
10 | chr16 left-arm | 50 | No functional enrichment | R70 | - | - | Disomy consequence |
11 | chr16:370 | 17 | chr8 translocated gene | - | SSU1 translocation | Not realized | Translocation consequence |