Figure 6

MAP utilizes the β-oxidation pathway under all culture conditions. MAP inside MAC-T cells (co-cultured and alone) and macrophages (cultured alone) upregulated genes involved in the β-oxidation pathway. Upregulated genes involved in β-oxidation were fadD, fadE, enoyl-hydratases, and a transcriptional regulator (MAP2591). Genes highlighted in dark blue were upregulated under single cell culture; underlined = macrophage, normal text = MAC-T. Genes highlighted in green were upregulated in MAC-T cells under co-cultured conditions.