Host-Mycobacterium avium subsp. paratuberculosis interactome reveals a novel iron assimilation mechanism linked to nitric oxide stress during early infection

Table 1 Host differential gene expression and comparisons

Comparison	All genes	Upregulated	Downregulated	Causation
Infected vs. Uninfected MAC-T cells	547	232	315	MAP infection *(A)*
Infected vs. Uninfected Co-cultured MAC-T cells	806	370	436	MAP infection *with* extrinsic factors from macrophages *(B)*
Infected vs. Uninfected Macrophages	488	342	146	MAP infection *(C)*
Infected vs. Uninfected Co-cultured Macrophages	570	263	307	MAP infection *with* extrinsic factors from MAC-T cells *(D)*
Infected Co-culture MAC-T cells vs. Infected MAC-T cells	695	594	101	MAP infection *and* extrinsic factors from macrophages *(E)*
Infected Co-cultured Macrophages vs. Infected Macrophages	826	452	374	MAP infection *and* extrinsic factors from MAC-T cells *(F)*
Infected Co-cultured MAC-T cells vs. Uninfected MAC-T cells	876	751	125	Extrinsic factors from macrophages *(G)*
Infected Co-cultured Macrophages vs. Uninfected Macrophages	602	347	255	Extrinsic factors from MAC-T cells *(H)* and MAP infection *(C)*