Table 7 Effects of mercurial on gene expression in cells
From: Comparative toxicogenomic responses of mercuric and methyl-mercury
Genes | SK-N-SH | HepG2 | HEK293 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C. elegans | Human | HgCl2 | MeHgCl | HgCl2 | MeHgCl | HgCl2 | MeHgCl | ||||||||||||
NOAEL | EC20 | EC50 | NOAEL | EC20 | EC50 | NOAEL | EC20 | EC50 | NOAEL | EC20 | EC50 | NOAEL | EC20 | EC50 | NOAEL | EC20 | EC50 | ||
wht-3 | ABCG2 | Not Detected | - | - | - | -2.0 | -3.0 | -5.3 | - | - | 1.9 | - | - | - | |||||
asp-7 | BACE1 | - | - | - | - | - | - | - | - | - | - | -1.9 | -3.1 | - | - | - | - | - | - |
BACE2 | - | 1.8 | 2.8 | - | - | - | - | - | - | - | - | - | - | - | -1.7 | - | - | - | |
ckb-2 | CHKA | - | - | 3.8 | - | - | - | - | - | -1.5 | - | -1.4 | -2.3 | - | - | 1.9 | - | - | - |
CHKB | - | - | 2.0 | 1.8 | 2.7 | 2.0 | - | - | - | -1.2 | - | -2.0 | - | - | - | - | - | - | |
elo-6 | ELOVL3 | - | - | 9.8 | - | - | - | - | - | - | - | 11 | 10 | - | - | 8.3 | - | - | 7.0 |
ELOVL6 | - | - | 1.8 | - | - | - | - | -2.0 | - | -2.2 | -2.4 | -2.8 | - | - | - | - | - | - | |
gcs-1 | GCLC | - | - | 2.6 | - | - | - | 2.5 | 2.6 | - | 2.8 | 2.1 | - | - | - | - | - | - | - |
pme-4 | PARG | - | - | - | - | - | - | - | - | - | - | - | -2.4 | - | - | - | - | - | - |