Table 8 Gene-mercurial interactions in human cells
From: Comparative toxicogenomic responses of mercuric and methyl-mercury
Gene | Mercurial | Interaction parameters (p-values) | ||
|---|---|---|---|---|
SK-N-SH | HepG2 | HEK293 | ||
ABCG2 | HgCl2 | NA | -1% (0.83) | -5% (0.56) |
MeHgCl | NA | -8% (0.038) | -28% (0.0068) | |
BACE1 | HgCl2 | -21% (0.057) | 21% (0.069) | -1% (0.92) |
MeHgCl | -11% (0.22) | -3% (0.68) | -28% (0.063) | |
BACE2 | HgCl2 | NA | NA | -2% (0.87) |
MeHgCl | NA | NA | -26% (0.30) | |
CHKA | HgCl2 | -26% (0.088) | -3% (0.72) | -20% (0.11) |
MeHgCl | -27% (0.037) | -21% (0.0028) | -31% (0.021) | |
CHKB | HgCl2 | -18% (0.39) | 19% (0.24) | 4% (0.71) |
MeHgCl | -10% (0.24) | 1% (0.92) | 5% (0.78) | |
ELOVL3 | HgCl2 | -21% (0.0066) | -4% (0.76) | -7% (0.62) |
MeHgCl | -5% (0.53) | 5% (0.35) | -37% (0.0023) | |
ELOVL6 | HgCl2 | -25% (0.35) | 58% (<0.001) | 3% (0.91) |
MeHgCl | -28% (0.071) | 3% (0.57) | 20% (0.43) | |
GCLC | HgCl2 | -15% (0.031) | 0% (1.00) | -25% (0.060) |
MeHgCl | -2% (0.45) | -22% (<0.001) | 3% (0.82) | |
PARG | HgCl2 | -15% (0.15) | -4% (0.59) | -22% (0.20) |
MeHgCl | 6% (0.61) | 1% (0.96) | -53% (0.0076) | |