Table 4 Combined chronic C. pneumoniae and recurrent A. actinomycetemcomitans infections-enriched GO terms in the inguinal AT transcriptome
GO category | Enriched GO term | GO term p-valuea | GO term-associated gene products | |
|---|---|---|---|---|
Up-regulatedb | Down-regulatedb | |||
GO:0005515 | Protein binding | <0.001 | Igk-V5, Igkv5-48, Igkv4-80, Igkv8-30, IgkV33, Igkv12-89, Igkv15-103, Igkv2-112, D6Mit97, S100a8, Ltf, LOC637260, LOC626347, Igl, Ighv1-62, Ighv6-3, LOC630305, Ighg3, Igh-4,Ighg, LOC100047788, Gm16971, Ngp, Chi3l3 | Aldh1a1, Adh7, Ddx17, Acta1, Bmp3, Igfbp6, Tnnc2, Lep, Dpt |
GO:0003823 | Antigen binding | <0.001 | LOC100047788, Igkv5-48, Igkv2-112 | - |
GO:0019731 | Antibacterial humoral response | 0.002 | LOC100047788 | - |
GO:0019730 | Antimicrobial humoral response | 0.002 | LOC100047788 | - |
GO:0051952 | Regulation of amine transport | 0.002 | - | Lep, Sncg |
GO:0042572 | Retinol metabolic process | 0.011 | - | Aldh1a1, Adh7 |
GO:0030534 | Adult behavior | 0.011 | - | Lep, Sncg |
GO:0014059 | Regulation of dopamine secretion | 0.011 | - | Sncg |
GO:0014046 | Dopamine secretion | 0.011 | - | Sncg |
GO:0006836 | Neurotransmitter transport | 0.011 | - | Slc6a13, Sncg |
GO:0042573 | Retinoic acid metabolic process | 0.013 | - | Aldh1a1, Adh7 |
GO:0002455 | Humoral immune response mediated by circulating immunoglobulin | 0.016 | LOC100047788 | - |
GO:0046928 | Regulation of neurotransmitter secretion | 0.020 | - | Sncg |
GO:0008344 | Adult locomotory behavior | 0.042 | - | Sncg |
GO:0032526 | Response to retinoic acid | 0.044 | - | Aldh1a1, Lep |
GO:2000366 | Positive regulation of STAT protein import into nucleus | 0.046 | - | Lep |
GO:0071298 | Cellular response to L-ascorbic acid | 0.046 | - | Lep |
GO:0060587 | Regulation of lipoprotein lipid oxidation | 0.046 | - | Lep |
GO:0051956 | Negative regulation of amino acid transport | 0.046 | - | Lep |
GO:0034439 | Lipoprotein lipid oxidation | 0.046 | - | Lep |