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Table 8 Relative changes in mRNA expression levels of selected genes in inguinal and epididymal AT

From: The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

 

Aa group

Cpn group

Cpn + Aa group

(n = 10)

(n = 10)

(n = 10)

Tissue

Gene

Median Log2fold change (IQRs)a

p-valueb

Inguinal AT

Mcp-1

-0.78 (1.96)

-0.31 (1.44)

-0.53 (1.76)

0.671

0.348

0.020

Mrc-1

-0.19 (1.05)

-0.17 (1.00)

0.02 (2.08)

0.671

1.000

1.000

CD68

0.44 (1.56)

0.25 (1.23)

0.03 (1.36)

0.203

0.061

0.437

Mif

0.57 (2.15)

0.40 (1.94)

-0.11 (1.67)

0.203

0.348

1.000

Slpi

4.73 (2.99)

-1.18 (3.55)

2.79 (6.50)

0.003

0.061

0.437

Mpo

4.30 (2.64)

-0.48 (3.75)

4.04 (7.01)

0.009

0.115

0.348

Epididymal AT

Mcp-1

-0.73 (1.97)

-0.41 (1.88)

-1.03 (1.46)

  

0.020

0.203

<0.001

 

Mrc-1

-0.16 (0.88)

0.60 (0.53)

-0.17 (0.99)

  

0.437

0.003

0.599

 

CD68

-0.39 (0.90)

0.58 (0.76)

0.55 (1.86)

  

0.120

0.034

0.600

 

Mif

-0.88 (0.70)

-0.13 (1.06)

-0.86 (0.67)

  

0.020

0.203

<0.001

 

Slpi

-0.89 (2.11)

0.20 (2.20)

-0.24 (2.07)

  

0.002

0.203

0.600

  1. aMedian Log2 fold change (IQRs) to the control mice. The control mice have been set into the value of 0.
  2. bThe Mann–Whitney U Test with the control mice as the reference group.
  3. Aa group, recurrent A. actinomycetemcomitans infection; Cpn group, chronic C. pneumoniae infection; Cpn + Aa group, combined recurrent A. actinomycetemcomitans and chronic C. pneumoniae infections; IQR, interquartile range; Mcp-1, monocyte chemoattractant protein 1; Mif, macrophage migration inhibitory factor, Mrc-1, mannose receptor C type 1; Mpo, myeloperoxidase; Slpi, secretory leukocyte peptidase inhibitor.