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Table 3 Performance of signature gene sets: cross prediction matrix showing prediction errors

From: A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children

Class comparison

Signature gene set

This study

Berry et al.[[4]]

Maertzdorf et al.[[6]]

 

Study

116 gene set

Minimal TB-LTBI set

Minimal TB-LTBI-HC set

Robust 10 gene q-PCR set

86 gene set

393 gene set

11 gene set

5 gene set

TB vs. LTBI

Berry et al.[4]

20.1

19.4

nda

nd

12.5

11.1

13.0

16.3

Maertzdorf et al.[5]

26.5

22.5

nd

nd

19.4

24.5

22.5

21.4

Maertzdorf et al.[6]

19.1

16.9

nd

nd

11.3

10.1

10.2

10.1

This study

11.1

11.1

nd

nd

50.0

50.0

33.0

50.0

average prediction error

19.2

17.5

nd

nd

23.3

23.9

19.7

24.5

TB vs. LTBI vs. HC

Berry et al.[4]

27.6

nd

23.9

34.9

20.1

14.1

27.3

30.4

Maertzdorf et al.[5]

48.6

nd

50.3

52.5

47.4

48.6

50.0

41.8

Maertzdorf et al.[6]

25.6

nd

25.6

48.9

17.8

21.3

26.2

32.8

This study

11.1

nd

14.8

14.8

66.7

74.1

74.1

70.4

  

28.2

nd

28.7

37.8

38.0

39.5

44.4

43.8

TB vs. LTBI vs. HC vs. other disease

Berry et al.[4]

37.4

nd

nd

nd

27.6

18.7

28.5

37.2

  1. Columns represent selected gene biomarker sets in the literature sets as well as in our dataset. Rows represent the studies on which the gene biomarker sets displayed in the columns were tested.
  2. a = not determined.