Gene symbol | Gene name | Function | Possible role in TB, lung disease or inflammatory processes |
---|---|---|---|
CHRM2 | Cholinergic muscarine 2 receptor | cAMP regulation on airway smooth muscle. | · Loss of muscarine receptor function is associated with airway hyperreactivity [12]. |
AMPH | Amphiphysin | Phagocytosis, clathrin-mediated endocytosis in alveolar macrophages [13]. | · Clathrin-mediated endocytosis in the lungs plays an important role in mediating the internalization of human rhinovirus and influenza A virus [14, 15]. |
· Inhibition of clathrin-mediated endocytosis led to inhibition of lipopolysaccharide (LPS) internalization and cytokine/chemokine release from macrophages stimulated by LPS [16]. | |||
SNX17 | Sorting nexin 17 | Intracellular binding protein for the adhesion molecule P-selectin [17]. | · P-selectin is important in the early phase of cell migration in TB infection and increased P-selectin serum levels are found in TB patients [18]. |
PIGC | Phosphatidylinositol glycan anchor biosynthesis class C | Biosynthesis of glycosylphosphatidylinositol [19]. | · Incorporation of the mycobacterial cell wall component lipoarabinomannan (LAM) into the macrophage cell membrane, a process that is dependent on successful insertion of a glycosylphosphatidylinositol anchor, is one of the key virulence factors for M. tuberculosis[20]. |
S100P | S100 calcium binding protein P | Calcium-binding protein involved in intracellular and extracellular calcium sensing and signal transduction [21]. | · M. tuberculosis-mediated inhibition of a cytosolic rise in calcium is one of the essential steps in phagosome maturation [22]. |
TAS2R46 | Taste receptor type 2 member 46 | Regulation of ciliary beat frequency through modulation of intracellular calcium concentration [23]. | · M. tuberculosis-mediated inhibition of a cytosolic rise in calcium is one of the essential steps in phagosome maturation [22]. Decreased expression of TAS2R receptors has been shown to lead to a decrease in intracellular calcium concentration [23]. |
· TAS2Rs are expressed on human airway smooth muscle where they cause bronchodilation through a localized calcium response [24]. | |||
STYXL1 | Serine/threonine/tyrosine interacting-like1 | Inhibition of formation of stress granules. | · Stress granules are host RNA cytoplasmic granules formed in response to infections by a pathway involving phosphorylation of the translation initiation factor eIF2α [25]. |
HBD | Hemoglobin delta | Encodes for the delta globin chain of HbA2. | · Involved in oxygen transport from the lung to the peripheral tissues. |
GLDC | Glycine dehydrogenase (decarboxylating) | Metabolic enzyme promoting cellular transformation. | · Altered GLDC expression has been correlated with survival time in lung cancer patients [26]. |
ACOT7 | Acyl-CoA thioesterase 7 | Expressed in macrophages, plays a role in inflammation through production of arachidonic acid. | · The molecular and cellular functions of ACOT7 have identified the enzyme as a candidate drug target in inflammatory diseases [27]. |