A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children

BMC Genomics

Table 5 Receiver operating characteristic analysis of selected genes

Gene	Down- or upregulation in TB	TB (n = 9) vs. LTBI (n = 29)				TB (n = 9) vs. HC (n = 25)			TB (n = 9) vs. pneumonia (n = 18)
		AUC	p-value	% Sens	% Spec	AUC	p-value	% Spec	AUC	p-value	% Spec
ACOT7	Upregulation	0.70	0.073	67	86	0.63	0.24	76	0.67	0.15	72
AMPH	Downregulation	0.55	0.86	56	52	0.60	0.91	76	0.56	1.00	61
CHRM2	Downregulation	0.63	0.17	56	62	0.62	0.33	46	0.52	0.87	44
GLDC	Upregulation	0.78	0.016	67	79	0.64	0.19	73	0.66	0.13	72
HBD	Upregulation	0.79	0.027	67	93	0.77	<0.01	78	0.79	<0.01	83
PIGC	Downregulation	0.62	0.29	55	76	0.80	<0.01	89	0.73	0.076	94
S100P	Upregulation	0.80	<0.01	89	76	0.58	0.77	35	0.64	0.24	39
SNX17	Downregulation	0.54	0.67	56	65	0.74	0.019	86	0.71	0.027	83
STYXL1	Upregulation	0.58	0.67	56	65	0.60	0.34	30	0.62	0.27	61
TAS2R46	Downregulation	0.65	0.31	67	72	0.76	0.017	84	0.73	0.071	78

ISSN: 1471-2164