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Figure 3 | BMC Genomics

Figure 3

From: Loss of WSTF results in spontaneous fluctuations of heterochromatin formation and resolution, combined with substantial changes to gene expression

Figure 3

BAZ1B homozygous knockout cells exhibit a unique nuclear phenotype. Representative images of RPE1 (a), BAZ1B-N6 (b) and BAZ1B-O4 (c) nuclei counterstained with DAPI. White arrow-heads in (b) and (c) point to block-containing nuclei. White arrows point to the DAPI-dense Barr body. Images were captured using settings defined for RPE1 that result in pixel saturation for block-containing BAZ1B -/- nuclei. (d) RPE1 and BAZ1B -/- nuclei stained with DAPI showing the appearance of large DAPI-dense blocks in a fraction of mutant cells, as indicated to the left.

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BMC Genomics

ISSN: 1471-2164

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