Table 2 DE genes associated with immune and inflammatory responses

Innate immune response

MALT1

XM_413722

mucosa associated lymphoid tissue lymphoma translocation gene 1

+2.847583

CLU

NM_204900

clusterin

+9.196763

DMBT1

CR353989

deleted in malignant brain tumors 1

+2.036204

DUSP4

NM_204838

dual specificity phosphatase 4

+19.50851

DUSP6

NM_204354

dual specificity phosphatase 6

+2.1367393

DUSP10

NM_001031044

dual specificity phosphatase 10

+2.5124102

LY96

BX931181

lymphocyte antigen 96

+4.2568717

SAMHD1

NM_001030845

SAM domain and HD domain 1

+5.7296877

ERAP1

AJ851612

endoplasmic reticulum aminopeptidase 1

+5.731377

HMGB1

NM_204902

high mobility group box 1

+3.24355

TMEM173

CR354327

transmembrane protein 173

+9.81937

CFI

XM_426329

complement factor I

+5.3699164

IL1R1

NM_205485

interleukin 1 receptor, type I

+2.814695

IRAK2

NM_001030605

interleukin-1 receptor-associated kinase 2

+2.1085246

IRF7

NM_205372

interferon regulatory factor 7

+4.334887

JUN

NM_001031289

jun proto-oncogene

+3.481312

MAP3K14

NM_001030927

mitogen-activated protein kinase kinasekinase 14

+2.0599

MYD88

NM_001030962

myeloid differentiation primary response gene (88)

+2.0273855

NCF2

CR391316

neutrophil cytosolic factor 2

+9.767744

NFKB2

NM_204413

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

+4.372285

MASP1

NM_213586

mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)

-5.984035

PELI1

NM_001012872

pellino homolog 1 (Drosophila)

-2.6004448

SIGIRR

NM_001199542

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

-3.878401

MRPS6

NM_001031486

mitochondrial ribosomal protein S6

-7.8250012

IFIH1

NM_001193638

interferon induced with helicase C domain 1

+11.25022

SRPK1

XM_419265

SFRS protein kinase 1

+2.4798062

TLR4

NM_001030693

toll-like receptor 4

+2.019901

TLR5

CR353090

toll-like receptor 5

-2.4051092

C1R

XM_416518

complement component 1, r subcomponent

+13.635473

C1S

NM_001030777

complement component 1, s subcomponent

+16.500757

C3

NM_205405

complement component 3

+25.31715

C4BPA

NM_204664

complement component 4 binding protein, alpha

-2.476029

C8B

BX934795

complement component 8, beta polypeptide

-2.8326783

TRIM25

XM_415653

tripartite motif-containing 25

+3.5009384

COLEC12

NM_001039599

collectin sub-family member 12

-11.011364

ITCH

XM_417330

itchy homolog E3 ubiquitin protein ligase (mouse)

+2.3843937

MARCO

NM_204736

macrophage receptor with collagenous structure

-3.0318317

FADD

XM_421073

Fas (TNFRSF6)-associated via death domain

-2.127713

IL18R1

NM_001145225

interleukin 18 receptor 1

+3.5603435

VNN1

NM_001039288

vanin 1

+30.900112

IL1RL1

NM_204275

interleukin 1 receptor-like 1

-9.989544

Cytokine-mediated signaling pathway

ADAR

AM179858

adenosine deaminase, RNA-specific

+2.2560015

USP18

CR354286

ubiquitin specific peptidase 18

+14.18105

EGR1

CR389000

early growth response 1

+4.516151

IRF8

NM_205416

interferon regulatory factor 8

+4.638908

IFI35

BX934680

interferon-induced protein 35

+4.3734093

IFNGR1

NM_001130387

interferon gamma receptor 1

+2.4954834

IL6

NM_204628

interleukin 6 (interferon, beta 2)

+75.02113

IL13RA2

NM_001048078

interleukin 13 receptor, alpha 2

+5.0171814

IRF1

NM_205415

interferon regulatory factor 1

+7.012157

IRF7

NM_205372

interferon regulatory factor 7

+4.334887

LIFR

NM_204575

leukemia inhibitory factor receptor alpha

+2.3569908

MX1

NM_204609

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

+48.569965

NCAM1

NM_001242604

neural cell adhesion molecule 1

-7.5168643

IP6K2

NM_001030596

inositol hexakisphosphate kinase 2

+2.4397569

PML

XM_413690

promyelocytic leukemia

+3.3186321

ZC3H15

NM_001006510

zinc finger CCCH-type containing 15

-2.916313

B2M

NM_001001750

beta-2-microglobulin

+6.515671

PTPN1

L20630

protein tyrosine phosphatase, non-receptor type 1

+3.4228158

PTPN2

NM_001199387

protein tyrosine phosphatase, non-receptor type 2

+2.9723573

CX3CL1

NM_001077232

chemokine (C-X3-C motif) ligand 1

+10.652483

STAT1

NM_001012914

signal transducer and activator of transcription 1, 91 kDa

+12.110944

STAT3

NM_001030931

signal transducer and activator of transcription 3 (acute-phase response factor)

+3.900449

VCAM1

BX950651

vascular cell adhesion molecule 1

-2.8632648

OASL

NM_205041

2′-5′-oligoadenylate synthetase-like

+101.55924

SOCS1

NM_001137648

suppressor of cytokine signaling 1

+15.976115

SOCS3

NM_204600

suppressor of cytokine signaling 3

+30.325502

CD44

NM_204860

CD44 molecule (Indian blood group)

+5.446098

CD74

NM_001001613

CD74 molecule, major histocompatibility complex, class II invariant chain

-7.0005507

Inflammatory response

CDO1

CR353781

cysteine dioxygenase, type I

-6.4660363

CEBPB

NM_205253

CCAAT/enhancer binding protein (C/EBP), beta

+3.5429432

IL23R

XM_422533

interleukin 23 receptor

+3.9536817

EPHX2

NM_001033645

epoxide hydrolase 2, cytoplasmic

-2.0498822

LY96

BX931181

lymphocyte antigen 96

+4.2568717

BLNK

NM_204908

B-cell linker

+3.781344

AOAH

XM_418835

acyloxyacyl hydrolase (neutrophil)

+3.389245

AOX1

NM_001038692

aldehyde oxidase 1

-3.0358417

IGFBP4

NM_204353

insulin-like growth factor binding protein 4

-2.5591307

IL6

NM_204628

interleukin 6 (interferon, beta 2)

+75.02113

IRAK2

NM_001030605

interleukin-1 receptor-associated kinase 2

+2.1085246

KNG1

XM_422766

kininogen 1

-2.1926415

LIPA

AJ719682

lipase A, lysosomal acid, cholesterol esterase (Wolman disease)

+3.7113423

LY75

NM_001037836

lymphocyte antigen 75

+3.9913418

NGFB

M26810

nerve growth factor, beta polypeptide

-2.035398

NOX4

NM_001101829

NADPH oxidase 4

-9.4226265

F11R

NM_001083366

F11 receptor

+4.464096

GAL

NM_001159678

galaninprepropeptide

+8.09671

SERPINA1

BX932103

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

-30.80776

S100A9

X61200

S100 calcium binding protein A9

+32.001503

CCL4

NM_001030360

chemokine (C-C motif) ligand 4

+10.783558

CCL17

XM_414018

chemokine (C-C motif) ligand 17

+4.898831

CCL19

BX929857

chemokine (C-C motif) ligand 19

+2.0884924

CCL20

NM_204438

chemokine (C-C motif) ligand 20

+4.089286

BMP2

NM_204358

bone morphogenetic protein 2

+3.6641774

TLR5

CR353090

toll-like receptor 5

-2.4051092

TNFAIP6

NM_001037837

tumor necrosis factor, alpha-induced protein 6

+51.35508

C3

NM_205405

complement component 3

+25.31715

SCG2

BX932277

secretogranin II (chromogranin C)

+3.5667899

ITCH

XM_417330

itchy homolog E3 ubiquitin protein ligase (mouse)

+2.3843937

VNN1

NM_001039288

vanin 1

+30.900112

NMI

BX950337

N-myc (and STAT) interactor

+3.1200686

CHST2

XR_027120

carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2

-2.5672126

HDAC9

CR354257

histone deacetylase 9

-6.544272