Figure 4

Comparison of model predictions and imaging flow-cytometry measurements of the quantitative cell cycle profiles. a) HSL1, b) CLB2, c) CDC28 tetraploid deletion series; d) CDC28 diploid series. Proportion of cells relative to WT in G1 (experiment: grey squares; model prediction: black squares) and S/G2 (experiment: grey triangles; and model prediction: black open triangles). e) Relative accumulation in the G1 or G2 phase of the cell cycle for the diploid cdc28/cdc28 + cdc28-as1 strain with increasing inhibitor concentration, f) Effect of increasing concentrations of 1 nm-PP1 specific inhibitor on the growth rate relative to the untreated cdc28/cdc28 + cdc28-as1 strain and to cdc28/cdc28 + CDC28 treated with the same inhibitor concentration, with mRNA level/growth rate relationships from the tetraploid series indicated for comparison.