Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues

Table 1 Weight changes of study animals

		Absolute weight [g]		Weight change to initial weight within groups [g]
ZT		Fed (n = 5)	Fasted (n = 5)	Fed (n = 5)	Fasted (n = 5)
2	0 h	26.7 ± 0.6	-	−0.21 ± 0.62	-
5	3 h	28 ± 0.74	26.2 ± 0.65	−0.13 ± 0.14	−2.13 ± 0.2
8	6 h	25.5 ± 1.73	28 ± 0.68	−1.14 ± 0.11	−2.26 ± 0.19
14	12 h	26.8 ± 0.93	24.8 ± 0.57	−1.09 ± 0.15	−2.96 ± 0.14**
26	24 h	25.1 ± 0.69	22.9 ± 0.33	−0.48 ± 0.15	−3.5 ± 0.14**
50	48 h	26.9 ± 0.44	22 ± 0.55***	−0.66 ± 0.29	−5.9 ± 0.42***

Significant differences were determined with a 2-way ANOVA followed by a Bonferroni posttest to determine significance for each time point (in bold: **p < 0.01; ***p < 0.001). ZT: zeitgeber time (hours).

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