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Figure 3 | BMC Genomics

Figure 3

From: The periodontal pathogen Porphyromonas gingivalis changes the gene expression in vascular smooth muscle cells involving the TGFbeta/Notch signalling pathway and increased cell proliferation

Figure 3

The protein-protein interaction network and SPIA analysis of the 28 up-regulated genes related to positive regulation of cell proliferation and 21 down- regulated genes related to negative control of cell proliferation. The network (A) was mapped using STRING, and the confidence parameter was set as 0.15. Lines between proteins stand for possible interactions, and are color-coded based on the type of interaction. In SPIA analysis (B), X-axis indicates probability to observe differentially expressed genes on the pathway; y-axis refers to the probability to observe perturbation of genes within pathways. Each number refers to a KEGG pathway ID. Pathways above the blue line are significant at 5% after FDR correction; those above the red lines are significant at 5% after Bonferroni correction. 49 genes were analyzed by SPIA analysis. The Notch pathway is shown as a yellow dot and TGF-beta pathway is shown as a green dot.

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BMC Genomics

ISSN: 1471-2164

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