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Figure 6 | BMC Genomics

Figure 6

From: The periodontal pathogen Porphyromonas gingivalis changes the gene expression in vascular smooth muscle cells involving the TGFbeta/Notch signalling pathway and increased cell proliferation

Figure 6

TGF-β and NOTCH activation in AoSMCs stimulated with P. gingivalis . Treatment of AoSMCs with viable P. gingivalis, increases the mRNA expression level of TGF-beta. TGF-beta is secreted as a latent complex which can be activated by a number of agents. The activation of TGF-beta interacts with TGFRII and this complex further phosphorylates TGFRI to activate the Smad pathway by phosphorylation at the carboxyl terminus. During this process, Smad anchor for receptor activation (SARA) can facilitate TGF-beta receptor complex to bind to R-Smads (Smad 2/3). Once the R-Smads being phosphorylated, they bind to Co-Smads to form a complex which go into nucleus and regulates the transcription of several targets genes involved in atherosclerosis. Beside this, TGF-beta and NOTCH pathway can collaborate with each other by direct interaction between Smad3 and NICD.

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BMC Genomics

ISSN: 1471-2164

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