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Figure 8 | BMC Genomics

Figure 8

From: Quantitative high-throughput profiling of snake venom gland transcriptomes and proteomes (Ovophis okinavensis and Protobothrops flavoviridis)

Figure 8

Alignment of two Ovophis transcripts [AB852005, AB852006] with myotoxin a [156]and its precursor, crotamine [155], growth-arresting peptide [179], and crotasin [180]. All of these toxins utilize the same scaffold with 35-48 residues and three disulfide bonds. The Ovophis transcripts share more features with crotasin and GAP, and they are generally less basic than crotamine and myotoxin a (positions 24, 28, 29, 36, 38, 49, 53, and 55). They lack Met-50 and Trp-54 of the small myotoxins and Trp-56 of the myotoxins and GAP. Both Ovophis transcripts bore the sequence RVHGRTSFS upstream from the putative signal peptide (not shown).

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