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Table 3 KEGG pathway results from HEAT analysis grouped by pathway class

From: STaRRRT: a table of short tandem repeats in regulatory regions of the human genome

   

STaRRRT

Exon

Intron

Term

ID

Genes

Enrich

p-value

Enrich

p-value

Enrich

p-value

Metabolism

Purine metabolism

230

126

1.94

0.020

-

-

2.44

0.006

Glycine, serine and threonine metabolism

260

53

-

-

-

-

3.33

0.006

Glycosaminoglycan degradation

531

12

-

-

7.14

0.006

-

-

Inositol phosphate metabolism

562

54

3.04

0.002

-

-

2.70

0.028

Glycan structures - biosynthesis 1

1030

40

3.24

0.005

-

-

-

-

Glycan structures - degradation

1032

18

-

-

6.00

0.006

-

-

Development/Cell growth and death

Apoptosis

4210

111

2.21

0.006

2.13

0.050

2.11

0.028

Dorso-ventral axis formation

4320

80

2.03

0.048

-

-

2.73

0.007

Axon guidance

4360

114

2.25

0.004

2.38

0.016

2.18

0.020

Signal transduction/Environmental information processing/Cell communication/Cell motility

Calcium signaling pathway

4020

108

3.23

8.6E-07

2.50

0.012

2.30

0.015

Phosphatidylinositol signaling system

4070

64

3.09

0.001

2.57

0.050

2.50

0.028

Wnt signaling pathway

4310

126

2.32

0.002

2.14

0.029

-

-

VEGF signaling pathway

4370

155

2.33

0.001

2.09

0.020

1.89

0.032

Focal adhesion

4510

120

2.33

0.002

2.42

0.012

2.20

0.015

Adherens junction

4520

166

1.76

0.031

2.50

0.002

2.30

0.004

Tight junction

4530

101

1.95

0.038

2.68

0.007

-

-

Gap junction

4540

116

2.32

0.002

2.19

0.032

2.41

0.007

Jak-STAT signaling pathway

4630

140

-

-

2.73

0.002

-

-

Regulation of actin cytoskeleton

4810

98

2.26

0.007

2.41

0.024

2.24

0.026

Immune system

Hematopoietic cell lineage

4640

19

-

-

-

-

5.39

0.006

T cell receptor signaling pathway

4660

167

1.89

0.011

2.50

0.002

-

-

B cell receptor signaling pathway

4662

160

1.75

0.037

2.61

0.002

-

-

Leukocyte transendothelial migration

4670

99

1.88

0.051

2.73

0.006

2.06

0.043

Nervous system

Long-term potentiation

4720

125

2.34

0.002

2.17

0.028

-

-

Long-term depression

4730

142

2.21

0.002

2.18

0.020

1.96

0.028

Endocrine system

Insulin signaling pathway

4910

195

1.98

0.002

2.32

0.002

2.18

0.004

Adipocytokine signaling pathway

4920

150

-

-

3.01

1.3E-04

1.96

0.028

Human diseases

Type II diabetes mellitus

4930

22

3.16

0.051

-

-

5.33

0.004

Epithelial cell sig. in H. pylori infection

5120

150

2.17

0.002

2.41

0.006

2.16

0.010

Colorectal cancer

5210

82

2.00

0.051

-

-

2.68

0.008

  1. Results from gene set enrichment analysis of the set of transcripts with STaRRRT STRs are shown alongside results for transcripts with STRs located in exons and transcripts with the highest density of high purity STRs in the introns. Results shown are FDR-corrected p-values. A KEGG pathway is only presented in the table if at least one of the STaRRRT, exon or high density intron results has an FDR-corrected p-value of less than 0.01. Columns with “-“ characters are those sets unenriched (so p > 0.05 before FDR correction). “Genes” is the number of entities in each set and “Enrich” is the ratio of the number of transcripts observed with STRs relative to that expected.