Skip to main content

Table 3 KEGG pathway results from HEAT analysis grouped by pathway class

From: STaRRRT: a table of short tandem repeats in regulatory regions of the human genome

    STaRRRT Exon Intron
Term ID Genes Enrich p-value Enrich p-value Enrich p-value
Metabolism
Purine metabolism 230 126 1.94 0.020 - - 2.44 0.006
Glycine, serine and threonine metabolism 260 53 - - - - 3.33 0.006
Glycosaminoglycan degradation 531 12 - - 7.14 0.006 - -
Inositol phosphate metabolism 562 54 3.04 0.002 - - 2.70 0.028
Glycan structures - biosynthesis 1 1030 40 3.24 0.005 - - - -
Glycan structures - degradation 1032 18 - - 6.00 0.006 - -
Development/Cell growth and death
Apoptosis 4210 111 2.21 0.006 2.13 0.050 2.11 0.028
Dorso-ventral axis formation 4320 80 2.03 0.048 - - 2.73 0.007
Axon guidance 4360 114 2.25 0.004 2.38 0.016 2.18 0.020
Signal transduction/Environmental information processing/Cell communication/Cell motility
Calcium signaling pathway 4020 108 3.23 8.6E-07 2.50 0.012 2.30 0.015
Phosphatidylinositol signaling system 4070 64 3.09 0.001 2.57 0.050 2.50 0.028
Wnt signaling pathway 4310 126 2.32 0.002 2.14 0.029 - -
VEGF signaling pathway 4370 155 2.33 0.001 2.09 0.020 1.89 0.032
Focal adhesion 4510 120 2.33 0.002 2.42 0.012 2.20 0.015
Adherens junction 4520 166 1.76 0.031 2.50 0.002 2.30 0.004
Tight junction 4530 101 1.95 0.038 2.68 0.007 - -
Gap junction 4540 116 2.32 0.002 2.19 0.032 2.41 0.007
Jak-STAT signaling pathway 4630 140 - - 2.73 0.002 - -
Regulation of actin cytoskeleton 4810 98 2.26 0.007 2.41 0.024 2.24 0.026
Immune system
Hematopoietic cell lineage 4640 19 - - - - 5.39 0.006
T cell receptor signaling pathway 4660 167 1.89 0.011 2.50 0.002 - -
B cell receptor signaling pathway 4662 160 1.75 0.037 2.61 0.002 - -
Leukocyte transendothelial migration 4670 99 1.88 0.051 2.73 0.006 2.06 0.043
Nervous system
Long-term potentiation 4720 125 2.34 0.002 2.17 0.028 - -
Long-term depression 4730 142 2.21 0.002 2.18 0.020 1.96 0.028
Endocrine system
Insulin signaling pathway 4910 195 1.98 0.002 2.32 0.002 2.18 0.004
Adipocytokine signaling pathway 4920 150 - - 3.01 1.3E-04 1.96 0.028
Human diseases
Type II diabetes mellitus 4930 22 3.16 0.051 - - 5.33 0.004
Epithelial cell sig. in H. pylori infection 5120 150 2.17 0.002 2.41 0.006 2.16 0.010
Colorectal cancer 5210 82 2.00 0.051 - - 2.68 0.008
  1. Results from gene set enrichment analysis of the set of transcripts with STaRRRT STRs are shown alongside results for transcripts with STRs located in exons and transcripts with the highest density of high purity STRs in the introns. Results shown are FDR-corrected p-values. A KEGG pathway is only presented in the table if at least one of the STaRRRT, exon or high density intron results has an FDR-corrected p-value of less than 0.01. Columns with “-“ characters are those sets unenriched (so p > 0.05 before FDR correction). “Genes” is the number of entities in each set and “Enrich” is the ratio of the number of transcripts observed with STRs relative to that expected.