TY - JOUR AU - Zhong, Shan AU - He, Xin AU - Bar-Joseph, Ziv PY - 2013 DA - 2013/11/15 TI - Predicting tissue specific transcription factor binding sites JO - BMC Genomics SP - 796 VL - 14 IS - 1 AB - Studies of gene regulation often utilize genome-wide predictions of transcription factor (TF) binding sites. Most existing prediction methods are based on sequence information alone, ignoring biological contexts such as developmental stages and tissue types. Experimental methods to study in vivo binding, including ChIP-chip and ChIP-seq, can only study one transcription factor in a single cell type and under a specific condition in each experiment, and therefore cannot scale to determine the full set of regulatory interactions in mammalian transcriptional regulatory networks. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-14-796 DO - 10.1186/1471-2164-14-796 ID - Zhong2013 ER -