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Table 1 Top five predicted TFs for liver, retina and B cell

From: Predicting tissue specific transcription factor binding sites

TF

Score

Known functions in the corresponding tissue

A. Liver

Hnf4a

2.22

Essential for maintaining hepatic gene expression and lipid homeostasis[41]

Rara

1.90

Important in maintaining liver homeostasis, and its disruption is linked to hepatocarcinogenesis[57]

Nr2f2

1.56

Expressed in liver, and known to regulate liver-specific genes[58]

Rxra

1.45

Important role in liver metabolism[59]

Tcf7

1.44

Downstream regulator in Wnt signaling which is critical in liver physiology and pathology[60]

B. Retina

Crx

4.28

Regulates photoreceptor gene expression[40]

Pitx3

4.26

Required for normal retina formation in Xenopus and zebrafish[61, 62]

E2F3

4.06

Involved in retina progenitor cell development[63]

Pitx2

3.92

Pitx2-deficient mouse exhibits ocular abnormalities[64]

Gsc

3.89

Unknown function in retina.

C. CD19+ B cell

Sfpi1

2.09

Essential regulator of B-cell differentiation[65]

Pou2f2

2.08

Required for T-cell independent B cell activation[66]

Spic

1.98

Promotes B cell differentiation[67]

Pou2f3

1.94

Unknown function in B cell, but has almost the same binding preference as Pou2f2

Elf4

1.70

Regulates proliferation of B cells[68]