Table 1 Top five predicted TFs for liver, retina and B cell
From: Predicting tissue specific transcription factor binding sites
TF | Score | Known functions in the corresponding tissue |
|---|---|---|
 A. Liver | ||
Hnf4a | 2.22 | Essential for maintaining hepatic gene expression and lipid homeostasis[41] |
Rara | 1.90 | Important in maintaining liver homeostasis, and its disruption is linked to hepatocarcinogenesis[57] |
Nr2f2 | 1.56 | Expressed in liver, and known to regulate liver-specific genes[58] |
Rxra | 1.45 | Important role in liver metabolism[59] |
Tcf7 | 1.44 | Downstream regulator in Wnt signaling which is critical in liver physiology and pathology[60] |
 B. Retina | ||
Crx | 4.28 | Regulates photoreceptor gene expression[40] |
Pitx3 | 4.26 | Required for normal retina formation in Xenopus and zebrafish[61, 62] |
E2F3 | 4.06 | Involved in retina progenitor cell development[63] |
Pitx2 | 3.92 | Pitx2-deficient mouse exhibits ocular abnormalities[64] |
Gsc | 3.89 | Unknown function in retina. |
 C. CD19+ B cell | ||
Sfpi1 | 2.09 | Essential regulator of B-cell differentiation[65] |
Pou2f2 | 2.08 | Required for T-cell independent B cell activation[66] |
Spic | 1.98 | Promotes B cell differentiation[67] |
Pou2f3 | 1.94 | Unknown function in B cell, but has almost the same binding preference as Pou2f2 |
Elf4 | 1.70 | Regulates proliferation of B cells[68] |