Figure 5

Gonadotropin-releasing hormone (GnRH) signaling pathway containing genes that are represented in the Partial Correlation Information Theory (PCIT) network “growth at the onset of puberty”. DAVID analysis indicating a nominally significant enrichment of genes from the GnRH signaling pathway that are associated with key- or supportive phenotypes for growth at the onset of puberty. Pathway components that are encoded by genes included in the PCIT network are colored in orange. Purple dots highlight betacellulin (BTC) and diacylglycerol kinase eta (DGKH), which were identified as major hubs in the growth network (Table 3). Arrows indicate molecular interactions or relations, dotted arrows indicate indirect effects. Graph adapted from the Kyoto Encyclopedia of Genes and Genomes (KEGG) (http://www.genome.jp/kegg-bin/show_pathway?hsa04912, accessed: 06/20/2013).