Chronic parasitization by Nosema microsporidia causes global expression changes in core nutritional, metabolic and behavioral pathways in honey bee workers (Apis mellifera)

Table 2 Functional analysis of transcripts regulated by co-infection

Functional category	GO term	GO biological process	p-value
Metabolism	GO:0042180	Cellular ketone metabolic process	2.42E-04
	GO:0006520	Cellular amino acid metabolic process	3.77E-04
	GO:0009152	Purine ribonucleotide biosynthetic process	1.71E-03
	GO:0044262	Cellular carbohydrate metabolic process	1.72E-02
	GO:0006629	Lipid metabolic process	2.31E-02
	GO:0042440	Pigment metabolic process	4.58E-02
	GO:0008152	Metabolic process	4.64E-02
Cell organization and transport	GO:0051234	Establishment of localization	3.56E-04
	GO:0006811	Ion transport	5.32E-04
	GO:0016192	Vesicle-mediated transport	2.10E-02
	GO:0033227	dsRNA transport	3.52E-02
Other	GO:0002376	Immune system process	1.99E-02
Other	GO:0046664	Dorsal closure, amnioserosa morphology change	2.28E-02

Transcripts significantly regulated by Nosema co-infection in worker fat body tissue were selected for functional analysis and overrepresented GO processes were identified.

ISSN: 1471-2164