Figure 5

NDRs of cell cycle-regulated and stress response genes overlap with different clusters of binding sites for transcription factors. (A) The cdc22, mik1 and SPCC306.11 genes are periodically expressed during the mitotic cell cycle. Clusters of binding sites for six different transcription factors [36] are indicated by vertical lines: (purple, Ace2; dark blue, FKH; green, MBF; black, Dbl10; orange and light blue, overrepresented motifs not associated to previously identified factors. (B) The mug143 and srk1 genes are overexpressed under oxidative stress. Binding sites for two transcription factors are indicated (see text for details). The nucleosome profile across the five regions in mitotic cells is shown on top of each diagram (red). The transcribed DNA strand during mitosis in the absence of stress corresponding to the five genes described above is shown (green).