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Table 1 The collection of 14 known host resistance genes

From: Prioritizing genes responsible for host resistance to influenza using network approaches

Entrez ID Gene symbol Gene description Mouse ortholog Cytoband Supporting evidence
4599 MX1 myxovirus (influenza virus) resistance 1 Mx1, Mx2 21q22.3 Mouse strains homozygous for Mx null allele fail to synthesize Mx protein and are influenza virus susceptible[22].
9437 NCR1 natural cytotoxicity triggering receptor 1 Ncr1 19q13.42 Ncr1-/- 129/Sv and C57BL/6 mice were lethal after influenza virus infection[23].
1234 CCR5 chemokine (C-C motif) receptor 5 Ccr5 3p21.31 Deaths among Ccr5-/- mice increase after infection with influenza A virus[22]. A large proportion of heterozygosity for the CCR5Δ 32 allele among white patients with severe disease was also found[24].
114548 NLRP3 NLR family, pyrin domain containing 3 Nlrp3 1q44 Mice lacking Nlrp3 exhibited dramatically increased mortality and a reduced immune response after exposure to the influenza virus[25]. Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation in human[26].
3105 HLA-A major histocompatibility complex, class I, A H2-D1 6p21.3 The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is associated with the HLA-A and -B phenotypes[27].
3106 HLA-B major histocompatibility complex, class I, B
2212 FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) Fcgr3 1q23 rs1801274 on FCGR2A is significantly (p < 0.0001, OR = 2.68, 95% CI: 1.69-4.25) associated with sever pneumonia after A/H1N1 infection in human[28].
84268 RPAIN RPA interacting protein Rpain 17p13.2 rs8070740 on RPAIN is significantly (p < 0.0001, OR = 2.67, 95% CI: 1.63-4.39) associated with sever pneumonia after A/H1N1 infection in human[28].
3456 IFNB1 interferon, beta 1, fibroblast Ifnb1 9p21 IFN-β-deficient mice carrying functional Mx1 alleles showed 20-fold lower in the 50% lethal dose of H7N7; and also substantially reduced resistance to H1N1 infection[29].
3586 IL10 interleukin 10 Il10 1q31-q32 A promoter polymorphism conferred a significantly decreased risk of adverse response to inactivated influenza vaccine[30].
708 C1QBP complement component 1, q subcomponent binding protein C1qbp 17p13.3 rs3786054 on C1QBP is significantly (p < 0.0001, OR = 3.13, 95% CI: 1.89-5.17 ) associated with sever pneumonia after A/H1N1 infection in human[28].
3811 KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 Kir3dl1 19q13.4 KIR3DL1/S1 and 2DL1 ligand-negative pairs were enriched among H1N1 ICU cases[31].
3803 KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 Kir3dl2 19q13.4 KIR2DL2/L3 ligand-positive pairs were enriched among H1N1 ICU cases[31].
10410 IFITM3 interferon induced transmembrane protein 3 Ifitm3 11p15.5 Mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus. A statistically significant number of hospitalized subjects were also shown enrichment for a minor IFITM3 allele that alters a splice acceptor site[32].