The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation

Table 1 Top 20 potential SUMO-1 targeting TFs before KSHV reactivation

Rank	Name	Transfac	TFBS # (in TSS±500 bp)	Peak # of TFBS (in TSS±500 bp)		% of TFBS Peak (in TSS±500 bp)		Gene #
Rank	Name	Transfac	TFBS # (in TSS±500 bp)	0 h	12 h	0 h	12 h	0 h	12 h
1	ETS1	V$CETS1P54_01	1587	341	262	21.5%	16.5%	294	229
2	GABPA/NRF-2	V$NRF2_01	1577	336	237	21.3%	15.0%	286	206
3	ELK1	V$ELK1_02	1667	333	254	20.0%	15.2%	279	215
4	USF1	V$USF_C	441	79	45	17.9%	10.2%	71	44
4	USF1	V$USF_Q6	1136	146	97	12.9%	8.5%	132	92
5	STAT1	V$STAT1_03	282	50	41	17.7%	14.5%	48	39
5	STAT1	V$STAT1_01	1179	146	122	12.4%	10.3%	134	110
6	STAT4	V$STAT4_01	106	17	17	16.0%	16.0%	4	4
7	MYC/MAX	V$MYCMAX_02	580	90	76	15.5%	13.1%	68	55
7	MYC/MAX	V$MYCMAX_01	784	104	88	13.3%	11.2%	93	68
8	CREB1	V$CREB_01	666	103	87	15.5%	13.1%	97	83
9	MAX	V$MAX_01	584	87	68	14.9%	11.6%	75	64
10	ATF-2	V$CREBP1_01	272	37	30	13.6%	11.0%	35	28
11	STAT3	V$STAT3_01	986	133	108	13.5%	11.0%	123	101
12	SREBF1/SREBP1	V$SREBP1_01	1038	140	108	13.5%	10.4%	110	93
13	MYCN	V$NMYC_01	1467	195	125	13.3%	8.5%	170	114
14	STAT6	V$STAT_01	570	75	59	13.2%	10.4%	66	54
15	ARNT	V$ARNT_01	835	108	89	12.9%	10.7%	102	87
16	ARID5B/MRF2	V$MRF2_01	478	61	57	12.8%	11.9%	56	52
17	E2F1/2/3/4/5	V$E2F_02	1301	166	121	12.8%	9.3%	149	110
18	PBX1	V$PBX1_01	220	28	21	12.7%	9.5%	28	21

ISSN: 1471-2164