The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation

Table 2 Top 20 potential SUMO-2/3 targeting TFs before KSHV reactivation

Rank	Name	Transfac	TFBS # (in TSS±500 bp)	Peak # of TFBS (in TSS±500 bp)		% of TFBS Peak (in TSS±500 bp)		Gene #
Rank	Name	Transfac	TFBS # (in TSS±500 bp)	0 h	12 h	0 h	12 h	0 h	12 h
1	ETS1	V$CETS1P54_01	1587	337	397	21.2%	25.0%	296	353
2	GABPA/NRF-2	V$NRF2_01	1577	320	379	20.3%	24.0%	274	335
3	ELK1	V$ELK1_02	1667	336	382	20.2%	22.9%	285	328
4	STAT4	V$STAT4_01	106	20	12	18.9%	11.3%	7	12
5	STAT1	V$STAT1_03	282	53	79	18.8%	28.0%	45	68
6	CREB1	V$CREB_01	666	124	164	18.6%	24.6%	114	152
7	ATF2	V$CREBP1_01	272	45	67	16.5%	24.6%	45	64
7	ATF2	V$CREBP1_Q2	1273	168	201	13.2%	15.8%	135	198
8	STAT6	V$STAT_01	570	92	122	16.1%	21.4%	85	110
9	MYC/MAX	V$MYCMAX_02	580	93	96	16.0%	16.6%	74	87
10	MAX	V$MAX_01	584	93	110	15.9%	18.8%	79	97
11	HLF	V$HLF_01	438	69	90	15.8%	20.5%	66	85
12	USF1	V$USF_C	441	69	86	15.6%	19.5%	64	78
13	ARID5B/MRF2	V$MRF2_01	478	74	100	15.5%	20.9%	68	91
14	NFYA/B/C	V$NFY_Q6	1557	217	295	13.9%	18.9%	176	250
14	NFYA/B/C	V$NFY_C	416	57	79	13.7%	19.0%	55	75
15	SREBF1/SREBP1	V$SREBP1_01	1038	144	179	13.9%	17.2%	100	170
16	STAT5A	V$STAT5A_02	982	135	155	13.7%	15.8%	109	133
17	ZEB1	V$AREB6_04	530	70	89	13.2%	16.8%	60	78
18	ARNT	V$ARNT_01	835	110	136	13.2%	16.3%	106	131
19	E2F1/2/3/4/5	V$E2F_02	1301	171	226	13.1%	17.4%	155	199
20	STAT3	V$STAT3_01	986	129	168	13.1%	17.0%	127	159

ISSN: 1471-2164