The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation

Table 4 Top 20 potential SUMO-2/3 targeting TFs after KSHV reactivation

Rank	Name	Transfac	TFBS # (in TSS±500 bp)	Peak # of TFBS (in TSS±500 bp)		% of TFBS Peak (in TSS±500 bp)		Gene #
Rank	Name	Transfac	TFBS # (in TSS±500 bp)	0 h	12 h	0 h	12 h	0 h	12 h
1	STAT1	V$STAT1_03	282	53	79	18.8%	28.0%	45	68
2	ETS1	V$CETS1P54_01	1587	337	397	21.2%	25.0%	296	353
3	PBX1	V$PBX1_01	220	28	55	12.7%	25.0%	28	54
4	ATF2	V$CREBP1_01	272	45	67	16.5%	24.6%	45	64
5	CREB1	V$CREB_01	666	124	164	18.6%	24.6%	114	152
6	GABPA/NRF-2	V$NRF2_01	1577	320	379	20.3%	24.0%	274	335
7	ELK1	V$ELK1_02	1667	336	382	20.2%	22.9%	285	328
8	IRF-1	V$IRF1_01	534	46	118	8.6%	22.1%	43	113
9	STAT6	V$STAT_01	570	92	122	16.1%	21.4%	85	110
10	FOXO4	V$FOXO4_02	456	28	97	6.1%	21.3%	28	75
11	NFATC1/2/3/4	V$NFAT_Q6	487	50	102	10.3%	20.9%	29	55
12	ARID5B/MRF2	V$MRF2_01	478	74	100	15.5%	20.9%	68	91
13	IRF-2	V$IRF2_01	601	48	125	8.0%	20.8%	63	93
14	SRY	V$SRY_01	523	32	108	6.1%	20.7%	30	91
15	HLF	V$HLF_01	438	69	90	15.8%	20.5%	66	85
16	IRF-7	V$IRF7_01	754	87	153	11.5%	20.3%	79	126
17	MEF2A	V$MEF2_01	455	36	91	7.9%	20.0%	28	72
18	GATA1	V$GATA1_04	191	14	38	7.3%	19.9%	13	35
19	POU3F2	V$POU3F2_02	246	17	48	6.9%	19.5%	17	43
20	USF1	V$USF_C	441	69	86	15.6%	19.5%	64	78

ISSN: 1471-2164