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Table 5 GO categories of SUMO targeting genes during KSHV reactivation

From: The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation

    SUMO-1 SUMO-2/3
   0 h 12 h 0 h 12 h
Pathway category Genes in category Genes identified p-value Genes identified p-value Genes identified p-value Genes identified p-value
Pathogen-influenced signaling Virus entry via endocytic pathways 99 14 2.59E-01 16 8.71E-02 13 3.35E-01 31 1.41E-03
Cellular immune response Antigen presentation pathway 40 8 9.77E-02 5 5.02E-01 8 8.71E-02 14 1.26E-02
CD40 signaling 70 11 1.87E-01 12 8.91E-02 11 1.67E-01 23 2.82E-03
HMGB1 signaling 99 15 2.19E-01 18 3.89E-02 13 3.96E-01 25 9.33E-02
IL-10 signaling 78 13 9.55E-02 14 4.07E-02 10 3.58E-01 19 9.55E-02
IL-15 signaling 67 8 5.43E-01 12 7.41E-02 8 5.15E-01 20 1.86E-02
IL-3 signaling 74 11 3.11E-01 12 1.74E-01 10 4.11E-01 23 1.41E-02
IL-8 signaling 205 29 1.52E-01 28 1.61E-01 29 1.25E-01 48 4.68E-02
NF-κB activation by viruses 82 12 1.99E-01 23 2.00E-02
p38 MAPK signaling 117 22 4.47E-02 18 2.10E-01 17 3.10E-01 26 3.80E-01
Toll-like receptor signaling 62 14 1.05E-02 9 2.65E-01 17 5.75E-02
Cytokine signaling IL-17A signaling in airway cells 72 9 4.33E-01 12 8.91E-02 10 2.72E-01 21 1.35E-02
Prolactin signaling 80 10 4.78E-01 13 1.21E-01 22 3.72E-02
Cancer Glioma signaling 112 17 1.03E-01 14 3.01E-01 29 1.55E-02
p53 signaling 96 18 5.13E-02 16 1.17E-01 16 1.24E-01 32 1.48E-03
Small cell lung cancer signaling 89 13 1.24E-01 13 1.02E-01 13 1.08E-01 27 6.03E-04
Sonic hedgehog signaling 33 6 1.65E-01 9 7.24E-03 5 3.03E-01
Cellular growth, proliferation and development Cleavage and polyadenylation of Pre-mRNA 12 5 1.32E-02 4 5.37E-02 3 1.87E-01 5 8.32E-02
EGF signaling 62 11 1.02E-01 8 4.05E-01 21 2.88E-03
FAK signaling 101 15 1.15E-01 12 4.06E-01 27 1.32E-02
JAK/Stat signaling 70 13 8.71E-02 13 7.08E-02 10 3.40E-01 26 5.37E-04
Oncostatin M signaling 35 5 4.55E-01 5 4.26E-01 12 3.55E-02
PDGF signaling 85 12 2.92E-01 12 2.54E-01 25 1.07E-02
Thrombopoietin signaling 63 8 4.22E-01 10 1.45E-01 17 4.90E-02
VEGF signaling 103 17 7.59E-02 19 1.66E-02 13 3.66E-01 25 7.59E-02
Cell cycle regulation Cyclins and cell cycle regulation 89 14 1.38E-01 11 4.05E-01 15 6.92E-02 24 2.75E-02
GADD45 signaling 22 4 2.26E-01 3 4.33E-01 5 8.32E-02 9 8.51E-03
Mitotic roles of polo-like kinase 70 11 2.46E-01 11 2.14E-01 14 3.89E-02 18 1.39E-01
Growth factor signaling ErbB2-ErbB3 signaling 60 11 9.55E-02 19 1.82E-02
Apoptosis April mediated signaling 43 8 1.10E-01 6 3.40E-01 8 1.00E-01 13 3.72E-02
Aryl hydrocarbon receptor signaling 161 24 8.51E-02 19 3.81E-01 23 1.07E-01 40 1.48E-02
Myc mediated apoptosis signaling 60 10 2.13E-01 10 1.85E-01 9 3.10E-01 20 1.05E-02
Cellular stress and injury Endoplasmic reticulum stress pathway 18 7 5.25E-03 5 6.61E-02 5 6.76E-02 7 6.03E-02
Disease-specific pathways Parkinson’s signaling 16 3 3.44E-01 4 1.31E-01 5 4.27E-02 4 4.32E-01
Neurotransmitters and other nervous system signaling Cholecystokinin/gastrin-mediated signaling 106 21 1.82E-02 13 5.05E-01 15 2.94E-01 24 2.59E-01
  1. bold: with statistical significance.