Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis

Table 1 List of most significantly up-regulated genes in in vitro activated T cells of psoriasis patients compared to healthy controls

Probe	Gene	Fold change	P value*	Full name
Upregulated genes
ILMN_1683678	*SPATS2L*	1.37	0.0009	Spermatogenesis associated, serine-rich 2-like
ILMN_1735014	*KLF6*	1.32	0.0012	Kruppel-like factor 6
ILMN_1703263	*SP140*	1.38	0.0025	SP140 nuclear body protein
ILMN_2322498	*RORA*	1.31	0.0041	RAR-related orphan receptor A
ILMN_2246956	BCL2	1.23	0.0062	B-cell CLL/lymphoma 2
ILMN_2397721	GLB1	1.23	0.0062	Galactosidase, beta 1
ILMN_1781285	DUSP1	1.21	0.0071	Dual specificity phosphatase 1
ILMN_2321064	BAX	1.24	0.0096	BCL2-associated X protein
ILMN_1731107	CCDC92	1.33	0.0136	Coiled-coil domain containing 92
ILMN_1729749	HERC5	1.72	0.0267	Hect domain and RLD 5
ILMN_2095660	TMEM156	1.29	0.0453	Transmembrane protein 156
ILMN_1681301	AIM2	1.42	0.0464	Absent in melanoma 2
ILMN_1767470	SCPEP1	1.26	0.0469	Serine carboxypeptidase 1
Downregulated genes
ILMN_1778617	TAF9	−1.25	0.0009	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
ILMN_2143250	FAR1	−1.20	0.0207	Fatty acyl CoA reductase 1
ILMN_1720114	GMNN	−1.20	0.0269	Geminin
ILMN_2135175	SNORD36A	−1.27	0.0303	Small nucleolar RNA, C/D box 36A

*Multiple-test corrected p-value.
List of genes with multiple-test corrected p-value < 0.05 and absolute change >1.2. Genes are classified into up-regulated or down-regulated groups and sorted by their statistical significance. Genes that were selected to validate are highlighted in bold.

ISSN: 1471-2164