Figure 2From: Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s diseaseActivation of microglia (microgliosis) coincides with focal axonal swellings in B6. APBTgmice. Little to no microgliosis (as judged by an increase in AIF1, red) was observed in B6.APBTg mice at 4 months but significant levels of microgliosis were observed in multiple brain regions at 8 months of age (arrowhead). Images taken from a region of the hippocampus as an example. AIF1 (allograft inducible factor, formerly IBA1) is a marker of microglia. Occasionally, this coincided with localized regions of axonal swellings (arrow, visualized using neurofilament, NFL, green). DAPI was used to identify nuclei. Scale bars = 50 μm.Back to article page